血管紧张素Ⅰ转换酶基因多态性与糖尿病视网膜病和糖尿病心肌梗塞关联  

The relationship of angiotensin Ⅰ-converting enzyme gene polymorphism with diabetic retinopathy and diabetes myocardial infarction

作　　者：武守山[1] 郭青梅[1] 刘阁玲[2] 张娟[1] 赵沉浮[1] 宁树成[1] 赵丽娜[1] 于芳[2] 伊红利[1] 

机构地区：[1]华北煤炭医学院生物技术系,唐山063000 [2]唐山工人医院

出　　处：《中华医学遗传学杂志》2004年第3期283-285,共3页Chinese Journal of Medical Genetics

基　　金：河北省科技厅科技攻关项目 (0 2 2 761 1 0 6)~~

摘　　要：目的　探讨血管紧张素 转换酶 ( angiotensin - converting enzyme,ACE)基因多态性与糖尿病视网膜病和心肌梗塞之间的关联性。方法　应用 PCR技术 ,对 1型糖尿病 33例视网膜病患者和 36例非视网膜病患者、2型糖尿病 6 8例伴心肌梗塞患者和 5 7例伴视网膜病患者以及 190例无并发症患者的ACE基因插入 /缺失型多态性进行了检测。结果　 ACE基因与视网膜病之间无关联。而 2型糖尿病心肌梗塞患者与非心肌梗塞患者比较 ,DD纯合子频率显著增高 ( 4 1.2 % vs 33.2 % ) ,D等位基因频率也显著增高 ,差异有显著性 ( P<0 .0 5 )。结论　 D等位基因 (相对风险为 1.5 0 )和 DD基因型 (相对风险为 1.33)可能是Objective To investigate the relationship of angiotensin I-converting enzyme ( ACE ) gene polymorphism to diabetic retinopathy and diabetes myocardial infarction. Methods ACE insertion/deletion(I/D) polymorphism was determined by PCR. Results No evidence showed that ACE gene was associated with diabetic retinopathy. By comparison of the type 2 diabetes patients with myocardial infarction versus those without-myocardial infarction, it was found that the frequencies of homozygote DD (41.2% versus 33.2%) and of allele D (64.7% versus 55.0%) increased remarkably; the difference was statistically significant ( P <0.05). Conclusion Allele D (RR=1.50) and genotype DD (RR=1.33) seemed to be a genetic risk factor for type 2 diabetes myocardial infarction.

关 键 词：糖尿病视网膜病 心肌梗塞 2型糖尿病 血管紧张素I转换酶 基因多态性 

分 类 号：R587.2[医药卫生—内分泌]