窒息新生儿脐血神经肽Y含量变化及意义  

Changes and significance of plasma neuropeptide Y in newborns with asphyxia

作　　者：胡电[1] 古航[2] 金志军[1] 刘彦[1] 熊英[1] 

机构地区：[1]第二军医大学长征医院妇产科,上海200003 [2]长海医院妇产科

出　　处：《中华围产医学杂志》2004年第3期145-147,共3页Chinese Journal of Perinatal Medicine

摘　　要：目的　探讨神经肽Y(neuropeptideY ,NPY)与新生儿窒息的关系。　 方法　采用放射免疫法测定 37例有新生儿窒息孕妇 (窒息组 )及 33例正常妊娠妇女 (对照组 )静脉血及脐血中NPY含量。　结果　 (1)窒息组脐血中NPY含量为 (187.4 7± 4 6 .6 3)ng/L ,对照组为 (115 .33±2 9.4 2 )ng/L。两组比较差异有显著性 (t =3.113,P <0 .0 1) ,重度窒息组与轻度窒息组间差异也有显著性(t=2 .0 0 1,P <0 .0 5 )。 (2 )窒息组母血浆NPY含量为 (78.94± 19.5 2 )ng/L ,对照组为 (85 .73±2 2 .95 )ng/L ,两组间差异无显著性 (t =1.72 1,P >0 .0 5 ) ,且轻、重度窒息组间差异也无显著性 (t =1.5 12 ,P >0 .0 5 )。(3)窒息组脐动脉血血气分析 :pH为 (7.0± 0 .1) ,PO2 为 (1.2± 0 .3)kPa ,PCO2为 (8.9± 0 .8)kPa ;NPY水平与脐血pH及PO2 显著负相关 (r =- 0 .4 5 1及 - 0 .4 92 ,P <0 .0 1) ,与PCO2 显著正相关 (r =0 .4 38,P <0 .0 1)。两组母血NPY水平无差异。　结论　NPY参与了新生儿窒息的病理变化过程 ,与新生儿窒息的发生发展密切相关。Objective To investigate the relationship between plasma neuropeptide Y(NPY) and asphyxia in newborns. Methods Thirty-seven patients with neonatal asphyxia (asphyxia group) and 33 healthy pregnant women(control group )in their third trimester were chosen. The concentrations of plasma NPY were measured by radioimmunoassay. Results The levels of NPY in umbilical artery plasma was (187.47± 46.63) ng/L in asphyxia group,and (115.33±29.42) ng/L in control group. There were significant difference between them ( P <0.01). The umbilical artery plasma NPY in severe asphyxia group increased significantly compared with the mild asphyxia group( P < 0.05). The umbilical artery blood gas analysis is the asphyxia group showed:pH (7.0±0.1); PO 2(1.2± 0.3) kPa; PCO 2 (8.9±0.8) kPa. The levels of NPY were negatively correlated with pH and PO 2 level in umbilical artery plasma ( P<0.01; P <0.05). Significant positive correlation was found between the level of NPY and PCO 2 ( P<0.05 ). There was no statistical difference in the levels of maternal plasma NPY between the control and asphyxia goup ( P >0.05). Conclusions The neonatal asphyxia was associated with NPY. NPY might play an important role in the pathophysiological changes in neonatal asphyxia.

关 键 词：脐血 神经肽Y 含量 新生儿窒息 静脉血 

分 类 号：R722.12[医药卫生—儿科]