肝素配伍阿斯匹林治疗妊娠合并抗磷脂综合征的妊娠结局  

Effect of heparin plus aspirin on pregnant outcome in women with antiphospholipid syndrome

作　　者：余艳红 万淑梅[1] 苏桂栋[1] 沈立勇[1] 张莉英[1] 龚时鹏[1] 

机构地区：[1]第一军医大学南方医院妇产科,广州510515

出　　处：《中华围产医学杂志》2004年第3期159-162,共4页Chinese Journal of Perinatal Medicine

基　　金：广东省重大社会问题联合攻关项目基金资助(ZKB0 470 1S)

摘　　要：目的　探讨肝素配伍小剂量阿斯匹林治疗妊娠合并原发性抗磷脂综合征 (antiphospho lipidsyndrome ,APS)对妊娠结局的影响。　 方法　回顾性分析 32 0例不明原因的反复妊娠丢失的妇女 ,排除其它常见原因后 ,进行抗心磷脂抗体 (anticardiolipinantibody ,aCL)IgG、IgM测定 ,36例阳性者接受肝素配伍小剂量阿斯匹林治疗。　结果　 36例患者中 34例获活婴 ,死胎 1例 ,流产 1例 ,妊娠成功率为 94 .4 % ,孕周 (35 .7± 3.2 )周。新生儿体重为 (2 96 0± 4 5 8)g ,较同期相同孕周新生儿体重(2 6 84± 32 4 ) g明显增加 (P <0 .0 5 )。　 结论　肝素配伍小剂量阿斯匹林治疗APS可明显改善妊娠结局 ,为治疗妊娠合并原发性APS的有效方法。Objective To investigate the efficacy of heparin plus low-dose aspirin on pregnant women with primary antiphospholipid syndrome(APS). Methods Three hundred and twenty women with unexplained pregnant failure were reviewed and anticardiolipin (aCL) immunoglobulin antibody G and M were tested. Heparin plus low-dose aspirin was given to 36 women with positive results. Results One fetal death and one embryo loss occured. The live birth rate was 94.4%(34/36) and the mean gestational week was (35.7±3.2) wks. The average birth weight was (2960±458) g which was significantly higher than the normal pregnancies (2684±324)g ( P <0.05). Conclusions Heparin plus low-dose aspirin regimen could improve pregnancy outcome in APS. It is effective for pregnant women with primary APS.

关 键 词：肝素 配伍 阿斯匹林 治疗 妊娠 抗磷脂综合征 妊娠结局 

分 类 号：R714.25[医药卫生—妇产科学]