系统性红斑狼疮患者外周血B淋巴细胞亚群与病情活动的相关性  

Correlation of peripheral B-lymphocyte subsets′change with the disease activity in systemic lupus erythematosus cases

作　　者：叶志中[1] 张丽君[1] 汪迅[1] 李博[1] 钟力[1] 李剑松[1] 庄俊汉[1] 高建华 

机构地区：[1]广东医学院附属福田人民医院香蜜湖风湿病医院红斑狼疮科,518040 [2]深圳市广缘红斑狼疮研究所

出　　处：《中国药物与临床》2004年第6期420-422,共3页Chinese Remedies & Clinics

基　　金：广东省自然科学基金资助项目(021339)

摘　　要：目的探讨系统性红斑狼疮(SLE)患者外周血B淋巴细胞亚群的变化及其与病情活动的相关性。方法用流式细胞仪检测了27例SLE患者及16名正常对照人群的外周血B淋巴细胞亚群。SLE活动性的判断采用SLEDAI评分方法,其中缓解期的患者11例,活动期的患者16例。分析以上SLE患者外周血B淋巴细胞亚群变化及其与病情活动的相关性。结果SLE患者外周血B1淋巴细胞亚群的百分比、B1淋巴细胞亚群/B2淋巴细胞亚群的比值显著高于正常对照,但未见其与病情活动相关。结论SLE患者外周血B1淋巴细胞亚群存在异常,可能在SLE的发病中具有重要作用。Objective To study B-lymphocyte subsets in peripheral blood of patients with systemic lupus erythematosos (SLE) and its relationship with disease activity.Methods Blood samples and clinical data from 27 patients were collected. B-lymphocyte subsets in peripheral blood of patients with SLE were detected by flow cytometry, the disease activity of SLE was measured by SLEDAI. The B-lymphocyte subsets and their relationship with disease activity were analyzed. Results The percentage of B-lymphocyte subsets in peripheral blood in patients with SLE and the ratio of B1-lymphocyte subset / B2-lymphocyte subset were higher than those in normal control, but had no correlation to disease activity. Conclusion The abnormality of B-lymphocyte subsets in peripheral blood of SLE patients may play a role in pathogenesis of SLE.

关 键 词：系统性红斑狼疮 外周血 B淋巴细胞亚群 病情活动 相关性 

分 类 号：R593.241[医药卫生—内科学]