药物涂层支架对冠心病治疗的初步观察  

A primary investigation: effect of drug eluting stent(CYPHER) on patients with atherosclerosis of coronary artery diease

作　　者：梁岩[1] 叶海鹏[1] 陈聪[1] 徐国帆[1] 陈杰山[1] 张凌宇[1] 邱伟兰[1] 蒋学军[1] 陆宇[1] 

机构地区：[1]广东省茂名市人民医院,茂名市525000

出　　处：《岭南心血管病杂志》2004年第3期186-187,共2页South China Journal of Cardiovascular Diseases

摘　　要：目的　评价雷帕霉素药物涂层支架 (CYPHER ,Cordis)对冠心病治疗效果的初步观察。方法　我院在 2 0 0 2年 10月至 2 0 0 3年 10月的 16例冠心病患者置入CYPHER支架 ,病变长度 18～ 35mm ,术前病变狭窄程度 (90±9 0 ) % ;心血管直径 (2 75～ 3 5mm)。观察药物涂层支架的手术成功率、术中并发症、住院期间及 1年内随访期间的心绞痛、再次血管重建、支架内血栓形成等发生。结果　手术即刻成功率 10 0 % ,术后造影病变残余狭窄 0 % ,支架完全覆盖病变 ,支架近远端无夹层 ,血流TIMI 3级。临床随访 1年13例患者心绞痛消失 ,12例术后 6个月复查冠脉造影 ,无支架内血栓形成 ,无血管再狭窄。结论　雷帕霉素药物涂层支架用于冠心病治疗是安全的 。Objectives To evaluate the effect of eluting stent (CYPHER) on patients with coronary artery Discase(CAD). Methods From october 2002 to october 2003, 16 patients with CAD were treated with eluting stent,The length of lesion was from 18～35 mm,the degree of stenosis before procedure was (90±9.0)%,and the vessel diameter before procedure was 2.75～3.5mm. We observed the procedure success and complication rates. The occurance of angina,in-stent thrombolysis,and the revascularization rates during the in-hospital and followed up one year. Results Immediate procedure Success rate was 100% with residual stenosis of 0%. All the lesions were covered fully by stents and the coronary flow reached TIMI Ⅲ. No dissection was observed in the optimal of stents. During the one year follow-up,the symptom of angina was disappeared in 13 patients,12 patients received coronary artery angiography (CAG)in 6 months and no restenosis or in-stent thrombolysis was observed. Conclusions Eluting stent(CYPHER)implantation is safe,and more effective than the Bone metal stents.

关 键 词：药物涂层支架 冠心病 治疗 雷帕霉素 支架植入术 

分 类 号：R654.2[医药卫生—外科学]