慢性乙型肝炎血清HBV DNA含量与HBeAg及ALT,AST的关系  

Relationship between HBV DNA concentration in serum with HBeAg, ALT and AST value in chronic hepatitis B

作　　者：郭海波[1] 李婪[1] 

机构地区：[1]广州医学院第二附属医院分子实验中心,广东广州510260

出　　处：《中国现代医学杂志》2004年第12期72-74,共3页China Journal of Modern Medicine

摘　　要：目的了解慢性轻、中型乙型肝炎患者HBV-DNA含量与血清标志物HBeAg和肝功能(ALT,AST)的关系。方法荧光定量PCR(FQ-PCR)技术检测77例轻、中型乙肝患者HBVDNA含量,ELISA法检测HBeAg,速率法检测ALT和AST。结果HBVDNA拷贝数量<105拷贝/ml时HBeAg阳性率低,>105拷贝/ml时HBeAg阳性率高,HBeAg阳性者HBV-DNA拷贝数为(6.71±1.24)lg,HBeAg阴性者HBV-DNA拷贝数是(3.48土0.11)lg,HBeAg阳性者HBV-DNA拷贝数显著高于阴性者(<0.05);HBV-DNA含量与ALT和AST无明显相关性。结论HBV-DNA含量与HBeAg阳性率有很好的一致性,HBV-DNA含量与ALT和AST无相关性。Objective: To explore the relationship between HBV DNA concentration in serum with HBeAg, ALT and AST value in chronic hepatitis B. Methods: Serum samples were detected for HBV DNA concentration by fluorescent quantitative PCR(FQ-PCR) in 77 cases with chronic hepatitis B. Results: The HBeAg positive rate was low when HBV DNA concentration was lower than 105 copies/ml, and was high when HBV DNA concentration was higher than 105 copies/ml. HBV concentration was (6.71±1.24) lg in HBeAg positive serum and it was (3.48±0.11) lg in HBeAg negative serum. There was a significant difference between them (P<0.05),HBV DNA concentration had no correlation with AST and ALT value. Conclusions: HBV DNA concentration is of identical tendency with HBeAg positive rate and not correlative with ALT and AST value.

关 键 词：荧光定量PCR HBEAG ALT AST 

分 类 号：R446.1[医药卫生—诊断学]