葛根素对β-淀粉样肽所致痴呆模型小鼠学习记忆的影响  

Effects of puerarin on AD animal model in mice induced by β-amyloid peptide

作　　者：杨东旭[1] 唐玉[1] 胡小敏[1] 刘进学[1] 陈怡[1] 金有豫[1] 

机构地区：[1]首都医科大学药理教研室药物研究所,北京100054

出　　处：《中国临床药理学与治疗学》2004年第6期650-652,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：首都医科大学基础与临床合作资助项目 (№ 0 0JL14 )

摘　　要：目的 :研究葛根素对 β 淀粉样肽所致痴呆模型小鼠学习记忆障碍的影响。方法 :以 β 淀粉样肽3μl(1mmol·L-1)icv制备小鼠学习记忆障碍模型 ,用Morris水迷宫法检测小鼠学习记忆能力。同时检测脑中及血中超氧化歧化酶 (SOD)、丙二酰醛(MDA)含量。结果 :葛根素 2 5和 5 0mg·kg-1均能改善模型小鼠的学习记忆 (P <0 .0 5或P <0 .0 1)。生化指标测定显示葛根素能使模型小鼠脑及血中的SOD增多、MDA减少 (P <0 .0 5或P <0 .0 1)。结论 :葛根素可对抗 β 淀粉样肽的神经毒性 。AIM: To observe the effects of puerarin on leaning and memorizing in mice induced by β-amyloid peptide. METHODS: β-amyloid peptide (25-35, 3 μl, 1.0 mmol·L -1) icv to mice was used as an AD animal model. Learning and memorizing ability in mice were inspected through Morris water maze test. In the meantime, the content of SOD and MDA in the mice of cerebral tissue and blood were also inspected. RESULTS: Puerarin 25 and 50 mg·kg -1 improved learning and memorizing ability in model mice (P< 0.05 or P< 0.01). And puerarin increased the content of SOD and reduce the content of MDA in cerebral tissue and blood of model mice. CONCLUSION: Puerarin can resist nerve poison of β-amyloid peptide, and the mechanism may be relevant to purge brain free radicals and to increase the activities of antioxidase.

关 键 词：葛根素 Β-淀粉样肽 学习记忆 脑自由基 

分 类 号：R285.5[医药卫生—中药学]