混料均匀设计考察益智方对去卵巢小鼠学习记忆的影响  

Study on learning and memorising of Yizhifang in ovariectomized mice by uniform design of experiments with mixtures

作　　者：余日跃[1] 余宙 胡王君 陈奇[1] 

机构地区：[1]江西中医学院中药药理教研室

出　　处：《中国临床药理学与治疗学》2004年第6期680-682,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金课题 (№ 3 95 60 0 89)

摘　　要：目的 :对益智方进行拆方分析 ,考察方中各类药对去卵巢小鼠学习记忆行为的影响。方法 :运用混料均匀设计法将组成益智方的三类中药配制成 5种不同的复方 ,通过空间学习记忆实验 ,测试用药小鼠的学习记忆能力。结果 :从上述不同配伍中筛选出一个最佳组方 ,具有明显改善去卵巢小鼠空间学习记忆的效果 ,方中主要成分为补肾类中药。结论AIM: To observe the effect of the Yizhifang and its analytic prescription on learning and memory in the ovariectomized mice. METHODS: Five pieces of different analytic prescriptions were composed of three groups of herbal medicines, applying the uniform design of experiments with mixtures (UDM).The mice were fed with these prescriptions and then the ability of learning and memory of these mice were measured in the test of special searching and location. RESULTS: One optimal prescription, mainly consisted of the medicine tonifying the kidney, can improve the ability of special learning and memory in ovariectomized mice. CONCLUSIONS: It is feasible and convenient to analyze the prescription of a larger formula with UDM.

关 键 词：混料均匀设计 学习和记忆 补肾中药 拆方分析 MORRIS水迷宫 

分 类 号：R285.5[医药卫生—中药学]