药物流产与手术流产对再次妊娠的影响  

Study on the Influence of Medical Abortion and Surgical Abortion on Subsequent Pregnancy

作　　者：邹燕[1] 罗军[2] 肖玉芳[3] 范玉娟[4] 罗蓉[4] 

机构地区：[1]四川大学华西医院中国循证医学中心 [2]四川省人民医院 [3]河北工程学院医学部附属医院妇产科 [4]四川大学华西第二医院

出　　处：《四川大学学报（医学版）》2004年第4期543-545,共3页Journal of Sichuan University(Medical Sciences)

摘　　要：目的　比较药物流产与手术流产对妇女再次妊娠孕期和分娩期的母儿影响 ,为临床选择恰当的人工流产方式提供依据。方法　按知情同意的原则 ,在曾经作过一次药物流产的健康孕妇中 ,随机选择 1 5 0例作为研究组 ;在曾经作过一次手术流产的健康孕妇中选择对照组 1 5 0例 ,研究组与对照组病例资料的基线的差异没有统计学意义 (P>0 .0 5 ) ,具有可比性。观察两组病例的孕期和分娩期母儿的并发症发生情况 ,并随访到分娩后 1周。结果药物流产后再次妊娠的先兆流产发生率、分娩期胎盘异常、早产儿和产后出血发生率比手术流产都低 (P<0 .0 5 ) ,其他结果在两组间的差异没有统计学意义。结论　药物流产对再次妊娠母儿的影响可能小于手术流产 ,故可以作为终止非意愿妊娠的首选 。Objective To evaluate and compare medical abortion versus surgical abortion in respect of their influence on the safety of the mother and baby in the subsequent pregnancy and parturition. Methods Based on the principle of informed consent of subjects, 150 healthy pregnant women with a past history of having experienced medical abortion once were included in the study group (also called medical abortion group), and in the same period, 150 healthy pregnant women with a past history of having experienced surgical abortion once were enrolled into the comparison group (also called surgical abortion group). From then on, all the pregnant women in the two groups were followed up till a week after labor. The baseline data of the two groups were comparable ( P >0.05). The rates of complications observed in these women during pregnancy and labor were evaluated. Results The incidence rates of miscarriage, placental abnormality, premature delivery and postpartum hemorrhage in the study group were significantly lower than those in the comparison group ( P <0.05). No significant differences on other variables were observed between the two groups. Conclusion Medical abortion is probably safer than surgical abortion in respect of their influence on subsequent pregnancy. So, provided there is less contraindication, medical abortion may be the choice for terminating unwanted pregnancy, especially for those women without a child.

关 键 词：药物流产 手术流产 再次妊娠 临床研究 

分 类 号：R714.21[医药卫生—妇产科学]