半叶马尾藻多糖对γ射线氧化损伤小鼠的保护作用  

Protective Effects of Sargassum Hemiphyllum polysaccharideson the Oxidative Damage Induced by γ-Rays in Mice

作　　者：孟庆勇[1] 刘志辉[1] 郑辉[2] 徐美奕[1] 

机构地区：[1]广东医学院分析中心,广东湛江524023 [2]暨南大学医学院生理教研室,广东广州510632

出　　处：《中国海洋大学学报（自然科学版）》2004年第4期589-593,共5页Periodical of Ocean University of China

基　　金：广东省湛江市科技重点攻关项目 (994 5 )资助

摘　　要：采用检测小鼠血浆和肝脏超氧化物歧化酶 (SOD)、过氧化氢酶 (CAT)和丙二醛 (MDA)的方法 ,观察半叶马尾藻多糖 [Sargassum hemiphyllum (Turner) C.Ag. polysaccharides,SHP]对2 Gyγ射线损伤小鼠氧化自由基的影响。结果发现 2 0 mg/ kg和 4 0 mg/ kg的 SHP不仅能明显降低辐射损伤小鼠血清和肝脏的 MDA含量 ,而且能够提高辐射损伤小鼠 SOD和 CAT的活性 ,并呈剂量依赖性增强。 1 0 mg/ kg的 SHP对辐射损伤小鼠肝脏 SOD、小鼠血浆和肝脏 CAT也有明显的促进作用。To observe the effect of Sargassum Hemiphyllum polysaccharides (SHP) onthe oxidative damage we detected the activity of superoxide dismutase(SOD), catalase(CAT) and malonaldehyde(MDA) in the plasma and liver of radiated mice of 2 Gy γ rays. It is found that SHP(20mg/kg and 40mg/kg) can not only significantly(P<0.01) decrease the MDA content but also significantly(P<0.01) increase the activity of SOD and CAT in the plasma and liver in a dose dependent manner. SHP(10mg/kg) also significantly increase the activity of SOD in the liver and the activity of CAT in the plasma and liver of radiated mice. The results show that SHP have an inhibitory effect on lipid peroxidation and a free radical clearance effect in radiated mice.

关 键 词：半叶马尾藻多糖 Γ射线 辐射损伤 SOD CAT MDA 

分 类 号：R818.74[医药卫生—放射医学]