酮舍林侧脑室给药对清醒大鼠血压波动性及动脉压力感受性反射的影响  

Effects of Central-administered Ketanserin on Blood Pressure Variability and Baroreflex Function in Conscious Rats

作　　者：程勇[1] 孔宪波[1] 苏定冯[1] 

机构地区：[1]第二军医大学药理学教研室,200433

出　　处：《第二军医大学学报》1993年第4期339-343,共5页Academic Journal of Second Military Medical University

基　　金：国家自然科学基金;No.3880743

摘　　要：用计算机化清醒大鼠血流动力学测定技术研究了酮舍林侧脑室给药对血压(BP)、血压波动性(BPV)、动脉压力感受性反射血压控制功能(ABR-BP)和心率控制功能(ABR-HP)的影响。结果表明:(1)酮舍林侧脑室给药无明显的降压作用;(2)酮舍林具有中枢性降低BPV、升高ABR-BP和ABR-HP的作用;(3)BPV的降低与ABR-BP的升高有关,而与BP水平无关;同时也可以认为酮舍林升高ABR-BP在其降压机制中不起主要作用;(4)在用酮舍林后,ABR-BP与BPV之间无显著的负相关性。Using computerized analysis of hemodynamics in conscious unrestrained rats, we tested the effects of intracerebroventricular administration of ketanserin (50 μg), a special 5-HT2 antagonist, on blood pressure (BP), blood pressure variability (BPV), baroreflex-blood pressure control (ABR-BP), and baroreflex-heart period control (ABR-HP). The result are as follows: (1) There was no significant depression of blood pressure after intracerebroventricular administration of ketanserin; (2) Ketanserin could significantly decreased BPV, and enhanced ABR-BP and ABR-HP; (3) The decreasing of BPV was associated with enhancement of ABR-BP, but these changes were no related to the level of BP, indicating that the hypotension induced by ketanserin was not related to the enhancement of ABR-BP; (4) There was no significant negative relationship between ABR-BP and BPV after intracerebroventricular administration of ketanserin.

关 键 词：血压 血液动力学 高血压 降压药 

分 类 号：R972.4[医药卫生—药品]