布洛芬胺盐的合成与结构表征  

Syntheses and Structural Characterization of Amine Salts of Ibuprofen

作　　者：周金森[1] 廖成竹[1] 冯小龙[1] 蔡继文[1] 

机构地区：[1]中山大学化学与化学工程学院测试中心,广东广州510275

出　　处：《分析测试学报》2004年第4期18-21,共4页Journal of Instrumental Analysis

基　　金：广东省科技计划项目(2003C104030)

摘　　要：合成了两个布洛芬有机胺盐,并用元素分析、红外和X射线粉末衍射对其结构进行了表征,首次报道了布洛芬乙胺盐的晶体结构。乙胺盐C13O2H17·EtNH3(1)晶体为单斜晶系,空间群P21／c,晶胞参数a＝8.3859(15);b＝6.5048(11);c＝28.960(5) ;β＝93.128(4)°;R1＝0.0727;Rw2＝0.2276。该化合物极易溶于水。乙二胺盐C13O2H17·(NH3CH2CH2NH3)0.5(2)为层状结构,略溶于水。本文还对已发表的布洛芬化合物的结构进行了比较。This paper describes the syntheses and structural characterization of two amine salts of ibuproˉfenusing elemental analyses,IR and X_ray powder diffracˉtion techniques.The crystal structure of the ethylamine salt of ibuprofen(1)was reported for the first time.It crystallized in the space group P2 1 /c with cell parameters a=8.3859(15);b=6.5048(11);c=28.960(5);β=93.128(4)°;R1=0.0727;Rw2=0.2276.It is quite soluble in water,while the ethylenediamine salt of ibuprofen(2)is only slightly soluble in water and adopts a layered crystalline structure.The structural diversity of the ibuprofen molecule in various forms(i.e.,stereoisomers,salts,and adducts)was discussed.

关 键 词：布洛芬 胺盐 晶体结构 元素分析 红外光谱 X射线衍射 

分 类 号：O656.4[理学—分析化学] R971.1[理学—化学]