Graves病血清sCTLA-4与Th_1/Th_2细胞因子平衡偏离的关系  

Relationship between soluble CTLA-4 and shift of serum Th_1/Th_2 cytokine balance in patients with Graves′ disease

作　　者：林夏鸿[1] 李希圣[1] 林玲[1] 

机构地区：[1]福建医科大学附属第二医院内分泌科,泉州362000

出　　处：《中华内分泌代谢杂志》2004年第3期242-244,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：探讨Graves病 (GD)血清可溶性细胞毒性T淋巴细胞相关抗原 4(sCTLA 4)与Th1/Th2 细胞因子失衡的关系。结果显示sCTLA 4升高 ,IL 4明显降低 ,IFN γ无明显改变 ,IFN γ/IL 4升高 ,sCTLA 4与IL 4呈直线负相关。提示GD血清Th1/Th2 细胞因子失衡 ,呈Th2 低下型 ,与sCTLAThe relationship between soluble cytotoxic T lymphocyte associated antigen-4 (sCTLA-4) and imbalance of Th 1/Th 2 cytokines was investigated in patients with Graves′ disease. The results showed that sCTLA-4 was increased, IL-4 decreased. IFN-γ did not significantly change, IFN-γ/IL-4 was raised and there was a negative linear correlation between sCTLA-4 and IL-4, suggesting that imbalance of serum Th 1/Th 2 cytokines with a decline in Th 2 cytokine was associated with increased sCTLA-4.

关 键 词：GRAVES病 血清 SCTLA-4 TH1/TH2 细胞因子平衡偏离 

分 类 号：R581.1[医药卫生—内分泌]