新生儿缺氧缺血性脑病患者血NO/NOS和TNF测定的临床意义  

The clinical significance of determining the serum NO/NOS and TNF in patients with neonatal Hypoxic-ischemic encephalopathy

作　　者：潘坚伟[1] 史建青[1] 

机构地区：[1]南京医科大学附属常州第二人民医院检验科,江苏常州213003

出　　处：《淮海医药》2004年第5期360-361,共2页Journal of Huaihai Medicine

摘　　要：目的　探讨了新生儿缺氧缺血性脑病患者血清 NO/ NOS和 TNF含量及其临床意义。方法　应用生化法和放射免疫分析法对 38例新生儿缺氧缺血性脑病患者进行了血清 NO/ NOS和 TNF含量检测 ,并与 35名正常新生儿作比较。结果　血清患儿组血清 NO水平低于正常人组 (P<0 .0 1 ) ,而 NOS和 TNF水平则显著高于正常人组(P<0 .0 1 )。结论　测定血清 NO/ NOS和 TNF含量与患儿的危重程度发生发展。Objective To invesigate the contents of serum nitric oxide(NO) and tumor necrosis factor(TNF) levels in patients with neonatal hypoxic ischemic encephalopathy(HIE) and their clinical significance.Methods The serum levels of NO/NOS were determined by biochemical methods and TNF determined by RIA,in 38 patients with HIE and 35 Normal controls.Results The NO levels were lower than those in normal controls( P <0.01) while NOS and TNF were higher than those in normal controls in patients with HIE.Conclusion The contents of serum NO/NOS and TNF in HIE neonates were correlated to the clinical stage and severeness of the disease process.

关 键 词：新生儿 缺氧缺血性脑病 NO NOS TNF 测定 一氧化氮 一氧化氮合成酶 肿瘤坏死因子 血清 

分 类 号：R722.12[医药卫生—儿科]