豚鼠圆窗膜破裂引起耳蜗形态变化的探讨  

Effects of Round Window Membrane Rupture on Morphological Changes of Guinea Pig's Cochlea

作　　者：刘秀丽[1] 别旭[2] 

机构地区：[1]大连医科大学附属第一医院耳鼻咽喉科,大连116011 [2]大连医科大学附属第二医院耳鼻咽喉科

出　　处：《听力学及言语疾病杂志》2004年第4期254-255,T002,共3页Journal of Audiology and Speech Pathology

摘　　要：目的　探讨外淋巴瘘时耳蜗形态学变化。方法　选用 10只 (10耳 )豚鼠 ,刺破圆窗膜致使外淋巴液漏出 ,4小时后进行耳蜗组织形态学观察。结果　发现膜迷路水肿 2耳 (2 10 ) ;1耳出现血管纹剥离、耳蜗内静脉淤血、耳蜗内出血 ;7耳 (7 10 )没有明显异常变化。结论　圆窗膜破裂可导致部分耳蜗组织形态学异常。Objective Clinical reports on perilymphatic fistulae(PLF) of the round window membrane(RWM) have shown different degrees of hearing loss. For the unknown mechanisms of hearing loss, the morphological changes of cochlea with perilymphatic fistulae(PLF) was studied.Methods Among 10 guinea pigs, each ear on one side was punctured and the ear of another side was used as control. 4 hours after operation, the morphological changes of cochlea were observed.Results It was found that 2 ears with endolymphatic hydrops, 1 ear with strica vascularis stripped, venous hyperemia and hemorrhage in cochlea, 7 ears with no changes.Conclusion The study suggestes that the normal and the abnormal morphological changes of cochlea can all be seen after the rupture of RWM.

关 键 词：外淋巴瘘 耳蜗 组织学观察 豚鼠 

分 类 号：R764.5[医药卫生—耳鼻咽喉科]