Solid-Phase Total Synthesis of 1-β-Methylcarbapenem  

作　　者：Ming LEI Cheng MA Yan Guang WANG 

机构地区：[1]Department of Chemistry,Zhejiang University,Hangzhou 310027

出　　处：《Chinese Chemical Letters》2003年第1期6-8,共3页中国化学快报(英文版)

基　　金：This work was financially supported by the National Natural Science Foundation of China (No. 29972037).

摘　　要：A 1-b-methylcarbapenem analogue 6 was synthesized on polystyrene-diethylsilane resin (PS-DES) using 2-azetidinone bearing with 2-oxazolidone chiral auxiliary as starting material.A 1-b-methylcarbapenem analogue 6 was synthesized on polystyrene-diethylsilane resin (PS-DES) using 2-azetidinone bearing with 2-oxazolidone chiral auxiliary as starting material.

关 键 词：SOLID-PHASE synthesis of b-lactam carbapenem antibiotics. 

分 类 号：O621.3[理学—有机化学]