Isolation and Characterization of an Antimicrobial Polypeptide from Loach  

作　　者：Xian Zhi DONG Hui Bi XU Kai Xun HUANG Qiong LIU 

机构地区：[1]Department of Chemistry,Huazhong University of Science and Technology,Wuhan 430074

出　　处：《Chinese Chemical Letters》2003年第1期54-57,共4页中国化学快报(英文版)

摘　　要：A novel antimicrobial polypeptide was isolated and characterized from loach, Misgurnus anguillicaudatus. The polypeptide, named MAPP, is a single-chain polypeptide with Mw about 9,800 Dalton and pI about 4.78; the N-tag of MAPP was CFGWN. MAPP showed good inhibition against various bacteria including Bacillus subtilis, Escherichia coli and Staphylococcus aureus. MAPP could be used as a lead compound in antibiotics drug discovery.A novel antimicrobial polypeptide was isolated and characterized from loach, Misgurnus anguillicaudatus. The polypeptide, named MAPP, is a single-chain polypeptide with Mw about 9,800 Dalton and pI about 4.78; the N-tag of MAPP was CFGWN. MAPP showed good inhibition against various bacteria including Bacillus subtilis, Escherichia coli and Staphylococcus aureus. MAPP could be used as a lead compound in antibiotics drug discovery.

关 键 词：Misgurnus anguillicaudatus ISOLATION characterization. 

分 类 号：TQ464[化学工程—制药化工]