Osteogenesis process of tricalcium phosphate ceramics in vivo  

作　　者：戴红莲 李世普 闫玉华 李小溪 贾莉 

机构地区：[1]Biomaterials and Engineering Research Center, Wuhan University of Technology, Wuhan 430070, China

出　　处：《中国有色金属学会会刊：英文版》2003年第1期65-68,共4页Transactions of Nonferrous Metals Society of China

基　　金：Project(G19990 6 470 1)supportedbytheNationalKeyFundamentalResearchandDevelopmentProgramofChina

摘　　要：To investigate the osteogenesis of calcium phosphate ceramics, β-TCP ceramics were implanted into the condyle femur of rabbits, and tetracycline was injected termly. Specimens were host at 1, 2, 3, 4, 5, 6 months after implanted. The new bone formation and osteogenesis process were observed by the histomorphology, fluorescent microscope, SEM and EPMA. The results demonstrate that, osteogenesis is active, there are abundant osteoblasts on the surface of osteoid, mesenchymal cell hyperplasia and incursion is found in materials after 1 month. After 2 months, there is blood vessel formation and macrophage soakage within materials. Bone-island appears and connects by bone-bridge after 3 months. β-TCP ceramics degrade and are dispersed by new formation bone. Woven bone turns into bone lamella by rebuilding and calcification. The materials entirely change their original shape and combines with bone tissue as a whole after 6 months. The typical structure of spongy bone forms. It is confirmed that β-TCP is a degradable biocompatible artificial bone material which can incorporating in life.To investigate the osteogenesis of calcium phosphate ceramics, β-TCP ceramics were implanted into the condyle femur of rabbits, and tetracycline was injected termly. Specimens were host at 1, 2, 3, 4, 5, 6 months after implanted. The new bone formation and osteogenesis process were observed by the histomorphology, fluorescent microscope, SEM and EPMA. The results demonstrate that, osteogenesis is active, there are abundant osteoblasts on the surface of osteoid, mesenchymal cell hyperplasia and incursion is found in materials after 1 month. After 2 months, there is blood vessel formation and macrophage soakage within materials. Bone-island appears and connects by bone-bridge after 3 months. β-TCP ceramics degrade and are dispersed by new formation bone. Woven bone turns into bone lamella by rebuilding and calcification. The materials entirely change their original shape and combines with bone tissue as a whole after 6 months. The typical structure of spongy bone forms. It is confirmed that β-TCP is a degradable biocompatible artificial bone material which can incorporating in life.

关 键 词：Β-磷酸三钙 成骨作用 荧火性 生物降解 

分 类 号：TQ174[化学工程—陶瓷工业]