谷氨酰胺对COPD合并营养不良患者内皮细胞功能的影响  

Effect of glutamine on the endothelial function in COPD patients complicated with malnutrition

作　　者：周琪[1] 邱丽君[1] 汪维乐[1] 沈立松[1] 

机构地区：[1]上海第二医科大学新华医院检验科,上海200092

出　　处：《上海第二医科大学学报》2004年第5期368-370,共3页Acta Universitatis Medicinalis Secondae Shanghai

摘　　要：目的 研究谷氨酰胺对内皮细胞功能的影响,探讨其在呼吸衰竭合并营养不良患者治疗中的作用。方法 将43例慢性阻塞性肺病(COPD)患者分为谷氨酰胺组(Glu)和非谷氨酰胺组(NGlu),按1.5 REE由营养师指导饮食10 d,Glu组将蛋白质减少30 g,以L-谷氨酰胺30 g取代,10 gtid。前后均采血检测NO、NOS、vWF及ET-1。结果 Glu组NO、ET-1与NGlu组有显著差异(P<0.01),两组vWF也有明显差异(P<0.05),NOS无显著差异。结论 谷氨酰胺对cOPD呼吸衰竭合并营养不良患者内皮细胞功能有显著改善。Objective To study the effect of glutamine on the endothelial function and discuss it's efficacy in the treatment of respiratory failure complicated with malnutrition. Methods Forty-three COPD patients were divided into two groups: glutamine (Glu) group and no glutamine ( NGlu) group. All patients abided by 1. 5 REE 10 d under the guidence of the nutritionists. The Glu group replaced 30 g protein with 30 g L- glutamine, 10 g tid. NO,NOS, vWF and ET-1 were determined before and after the experiment. Results There was significant difference in NO,ET-1 and vWF,but no obvious difference in NOS between the Glu group and NGlu group. Conclusion L- glutamine can obviously change the endothelial function of COPD respiratory failure patients complicated with malnutrition.

关 键 词：谷氨酰胺 慢性阻塞性肺病 营养不良 内皮细胞功能 作用机制 NO NOS VWF ET-1 

分 类 号：R563.9[医药卫生—呼吸系统]