Spectrofluorimetric Method for the Determination of Triamcinolone Acetonide  

作　　者：PanZu-ting YuJun-ping 

机构地区：[1]CollegeofChemistryandMolecularSciences,WuhanUniversity,Wuhan430072,Hubei,China

出　　处：《Wuhan University Journal of Natural Sciences》2004年第3期353-358,共6页武汉大学学报（自然科学英文版）

基　　金：SupportedbytheNationalNaturalScienceFoundationofChina (2 0 2 750 2 8)

摘　　要：A simple and highly sensitive method for the determination of triamcinolone acetonide in pharmaceutical formulations is presented. The approach is based on the fluorescence of production of triamcinolone acetonide oxidized by concentrated sulfuric acid. The effect of H2SO4, β-cyclodextrin (β-CD), solvent and cetyltrimethylammonium bromide (CTMAB) were discussed. And two analytical systems were established. One is CTMAB system, the linear range is 0–4.6×10?6 mol/L, and the detection limit is 3.59×10?8 mol/L. The other is β-CD and ethanol system, the linear range is 0–2.3×10?6 mol/L and the detection limit is 1.91×10?8 mol/L. The selectivity of analysis, the analytical figures of optimization, and the accuracy of the method are demonstrated with the determination of triamcinolone acetonide in pharmaceutical preparations. Key words triamcinolone acetonide - fluorimetry - CTMAB - β-cyclodextrin - pharmaceutical analysis CLC number O 657.39 Foundation item: Supported by the National Natural Science Foundation of China (20275028)Biography: Pan Zu-ting (1945-), male, Professor, research direction: analytical chemistry.A simple and highly sensitive method for the determination of triamcinolone acetonide in pharmaceutical formulations is presented. The approach is based on the fluorescence of production of triamcinolone acetonide oxidized by concentrated sulfuric acid. The effect of H2SO4, β-cyclodextrin (β-CD), solvent and cetyltrimethylammonium bromide (CTMAB) were discussed. And two analytical systems were established. One is CTMAB system, the linear range is 0–4.6×10?6 mol/L, and the detection limit is 3.59×10?8 mol/L. The other is β-CD and ethanol system, the linear range is 0–2.3×10?6 mol/L and the detection limit is 1.91×10?8 mol/L. The selectivity of analysis, the analytical figures of optimization, and the accuracy of the method are demonstrated with the determination of triamcinolone acetonide in pharmaceutical preparations. Key words triamcinolone acetonide - fluorimetry - CTMAB - β-cyclodextrin - pharmaceutical analysis CLC number O 657.39 Foundation item: Supported by the National Natural Science Foundation of China (20275028)Biography: Pan Zu-ting (1945-), male, Professor, research direction: analytical chemistry.

关 键 词：triamcinolone acetonide FLUORIMETRY CTMAB Β-CYCLODEXTRIN pharmaceutical analysis 

分 类 号：R977.11[医药卫生—药品] R917[医药卫生—药学]