周围神经损伤与组织工程修复的研究进展  

The Advances of Peripheral Nerve Damage and Tissue Engineering Repair

作　　者：孙晓红[1,2] 佟晓杰[3] 黄威[3,4] 

机构地区：[1]沈阳铁路局中心医院神经内科 [2]中国医科大学基础医学院人体解剖教研室,辽宁沈阳110001 [3]中国医科大学基础医学院人体解剖教研室 [4]沈阳军区总医院整形外科,辽宁沈阳110001

出　　处：《解剖科学进展》2004年第2期140-143,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金资助 (No 3 0 0 70 775 );辽宁省教委高校科研基金 ( 2 0 12 2 177)

摘　　要：近年来 ,周围神经损伤组织工程修复的研究取得了很大的进展。动物实验与临床研究主要聚焦于寻找理想的人工神经移植替代物、神经导管和种子细胞。神经导管有非降解或可降解两种 ,神经移植物有自体神经、同种异体神经及异种神经移植物 ,作为桥接神经缺损的支架有各自的优点与缺点。同时 ,培养、种植一定数量与高纯化度的具有分泌多种神经营养因子活性的施万细胞也是提高修复神经损伤效果的关键。Great progress was made on the study of injury and rehabilitating of peripheral nerve by tissue engineering in the recent years. The aim is to explore an ideal nerve graft substitute, nerve conduits and seed cells through a great deal of animal experiments and clinical studies. The nerve conduits include biodegradable nerve graft conduit and autologous nerve grafts. The nerve grafts are divided into allogeneic nerve grafts and heterogenous nerve grafts those have their benefits or disbenefits in bridging nerve gaps respectively. In addition, amount of cultured and highly purified Schwann cells play a key role as a seed cell in rehabilitating of peripheral nerve injury because of their secreting numerous neurotrophic factors.

关 键 词：周围神经损伤 组织工程 修复 人工神经移植物 周围神经移植 自体神经移植 

分 类 号：R651.3[医药卫生—外科学] R318[医药卫生—临床医学]