辐照氟银异体肌腱移植后体外微量细胞毒试验的观察  

An Investigation of Cytotoxicity Following Homograft of γ-Irradiated Tendon Incorporated with Norfloxacin and Silver

作　　者：邹立津[1] 辛国华[1] 曾元临[1] 史南枚[1] 余於戎[1] 毛远桂[1] 

机构地区：[1]江西医学院第一附属院烧伤中心,江西南昌330006

出　　处：《江西医学院学报》2004年第3期6-7,9,共3页Acta Academiae Medicinae Jiangxi

基　　金：江西省卫生厅跨世纪学科带头人资助课题 (G0 0 0 5 0 5 );江西省卫生厅资助课题 (G0 0 0 5 19)

摘　　要：目的　了解辐照氟银异体肌腱移植后宿主的免疫排斥反应。方法　采用 32只家兔随机分为 4组 :分别将制备好的辐照氟银异体肌腱 (A组 ) ,单纯辐照异体肌腱 (B组 ) ,深低温冷冻异体肌腱 (C组 )与自体肌腱 (D组 ) ,行肌腱移植。观察术后 3周和 8周宿主血清微量细胞毒性。结果　辐照组淋巴细胞死亡率与自体组无差异 (P >0 .0 5 ) ,均低于冷冻组 (P <0 .0 5 )。结论　辐照氟银异体肌腱具有明显的低抗原性 。Objective To observe the immune rejection response in host body after homograft of γ-Irradiated tendon incorporated with norfloxacin and silver immersion.Methods Thirty-two rabbits were randomly divided into four groups:irradiated allegoric tendon incorporated with norfloxacin and silver group(Group A),irradiated allegoric tendon group(Group B),deep-frozen allegoric tendon group(Group C)and autogeneic tendon group(Group D).They were then implanted into defects of Achilles tendons respectively.Immunologic property was observed at 3 weeks and 8 weeks after opetaiton.Results The contents of lymphocytoxicity showed lower in Group A,B and D than that in Group C(P<0.05).Conclusion γ-Irradiated tendon incorporated with norfloxacin and silver immersion is a good allegoric grafts,which can remarkably decreased the antigenecity.

关 键 词：辐照 肌腱 异体移植 细胞毒性 免疫反应 

分 类 号：R622.2[医药卫生—整形外科]