B型尿钠肽在心力衰竭危险分层及预后判断中的价值  

The role of plasma BNP in risk stratification and prognosis of patients with congestive heart failure

作　　者：励伟芬[1] 陈法余[1] 柳茵[1] 钟良[1] 徐曌[1] 刘霞[1] 陈玉林[1] 陈兆军[1] 黄洪章[1] 

机构地区：[1]杭州市第二人民医院,310015

出　　处：《浙江医学》2004年第6期415-416,419,共3页Zhejiang Medical Journal

摘　　要：目的探讨血浆中B型尿钠肽(BNP)水平在心力衰竭(心衰)的危险分层及预后判断中的价值。方法测定心衰组(66例)和对照组(22例)患者血浆BNP水平,并将BNP<100pg/ml组(33例)、100≤BNP<400pg/ml组(30例)与BNP≥400pg/ml组(25例)因心衰30d内再次住院率及心衰病死率进行对比,结合各组左室射血分数(LVEF)、血清尿酸(UA)、血清肌酸激酶同工酶(CK-MB)的水平,评价其对心衰的危险分层及预后判断的意义。结果心衰组血浆BNP水平均高于对照组,并随心功能的下降而升高(P<0.01),其水平与原发病无关(P>0.05)。随着BNP水平的升高,因心衰30d内再次住院率及心衰病死率增加(P<0.01),BNP水平较高者LVEF低、UA水平高,与CK-MB水平无关。结论血浆BNP水平随心功能的下降而升高,BNP较高者心衰的再次住院率及心衰病死率增加,提示BNP有助于心衰的危险分层及预后判断。Objective To evaluate the role of plasma B-type natriuretic peptide(BNP) in the risk stratification and the prognosis of patients with congestive heart failure(CHF). Methods The levels of plasma BNP were measured in 66 CHF patients (CHF group) and 22 patients without CHF (control group). Two groups were compared with the rate of readmission for worsening CHF in 30 days and the mortality due to heart failure among BNP<100pg/ml group(33 cases), 100≤BNP<400pg/ml group(30 cases) and BNP≥400pg/ml group(25 cases), and the relationship of BNP with LVEF, UA and CK-MB were evaluated. Results The plasma BNP levels in CHF group were higher than those in control group. The plasma BNP levels were significantly associated with the rate of readmission in 30 days and the mortality (P<0.01). Conclusion BNP levels can be used as a indicator for risk stratification and prognosis of patients with congestive heart failure.

关 键 词：B型尿钠肽 心力衰竭 危险分层 预后 诊断 

分 类 号：R541.6[医药卫生—心血管疾病]