以血液系统症状为首发症状的SLE15例分析  

Analysis of 15 SLE patients with initial hematological symptom

作　　者：郝建萍[1] 宋宣[2] 李玲[1] 

机构地区：[1]新疆医科大学第一附属医院血液科,新疆乌鲁木齐830054 [2]新疆武警总队医院检验科,新疆乌鲁木齐830000

出　　处：《新疆医科大学学报》2004年第3期244-245,共2页Journal of Xinjiang Medical University

摘　　要：目的:探讨以血液系统症状为首发症状的系统性红斑狼疮 (SL E)患者的临床特征。方法:回顾性分析15例 SL E患者的临床资料和实验室检查结果。 结果:本组患者临床表现及血象缺乏特异性 ,但所有病人均具备SL E相关的多种自身抗体阳性及不同程度的皮肤、粘膜、关节等症状 ,以贫血为主要表现者 10例 (6 6 .7% ) ,以出血为主要表现者 5例 (33.3% ) ,以溶血性贫血为主要症状者 2例 (13.3% ) ,白细胞减少者 7例 (4 6 .6 % ) ,血小板减少者 9例 (6 0 % ) ,全血细胞减少者 7例 (4 6 .6 % )。骨髓形态学改变缺乏特异性 ,主要表现为红系或粒系增生活跃 ,巨核数目正常或增多 ,但功能差。 2例溶血性贫血患者 Coom bs试验均为阳性 ,尿蛋白阳性者 11例 (73.3% )。 结论 :血液系统症状可以是 SL E的早期表现 ,当病人以血液系统症状就诊时 ,临床医生应提高警惕性 ,可进行与 SL E相关的检查 ,这对减少误诊率和提高诊断率至关重要。Objective: To explore the clinical characteristics of initial hematological symptom in patients with Systemic Lupus Erythematosus(SLE). Methods: Clinical features and hematological dates of 15 cases were reviewed and analysed. Results: These patients were short of specificity in clinical manifestation and hemogram.however, all cases possessed multiple SLE-related autoantibodies and varying extent dermal mucomembranous and arthral signs. The incidence of primary symptom in the 15 cases was as follow : 10 anemia (66.7%), 5 purpura (33.3%), 2 hemolytic anemia (13.3%), 7 leukopenia (46.6%), 9 thrombocytopenia (60.0%) and 7 pancytopenia (46.6%). The bone marrow examinations were short of specificity, 2 cases with hemolytic anemia Coombs'test positive. Proteinuria of 11 cases were positive (73.3%) . Conclusions: the clinical manifestation of hematological abnormality may be primary symptom of SLE. Physician should pay attention to it and determine multiple SLE-related autoantibodies.

关 键 词：系统性红斑狼疮 首发症状 血液系统症状 

分 类 号：R593.241[医药卫生—内科学]