Association Between Genital Ulcer Disease and HIV Seroprevalence among STD Patients in Guangzhou  

生殖器溃疡性疾病与HIV感染的相关性研究(英文)

作　　者：朱慧兰[1] 苏向阳 韩尔阳[1] 程文海[3] 武明昌[1] 林霭[1] 丘小珊[1] 张锡宝[1] 

机构地区：[1]广州市皮肤病防治所 [2]Department of Dermatology and Venerology, TheThird Affiliated Hospital of Zhongshan University,Guangzhou5 10630,China [3]江门市皮肤病院

出　　处：《Chinese Journal of Sexually Transmitted Infections》2004年第1期32-35,64,共5页中华性传播感染杂志（英文版）

基　　金：Financially supported by Guangdong Key project Foun-dation (No. 99049), and Medical Research Foundation ofGuangdong Province (No. B2001100).

摘　　要：Objectives: To understand genital ulcer disease(GUD) among patients attending sexually transmitteddisease (STD) clinics in Guangzhou, China, and itsassociation with HIV infection.Methods: Between September 9th, 1997 and Octo-ber 30th, 2002, 8 962 patients with STDs wereevaluated. 285 patients were diagnosed with GUD basedon clinical manifestations and microbiologic evalua-tions including dark field microscopy and serologytest for syphilis (RPR, TPPA). Swabs of each genitalulcer were processed in a multiplex PCR assay (M-PCR) for simultaneous detection of Herpes simplexvirus (HSV), Treponema pallium, and Haemophilusducreyi. Other STDs were classified by routine diag-nostic criteria, including microscopy or culture forNeisseria gonorrhoeae, Chlamydia trachomatis,Urea- plasma urealyticum, Human papillomavirus,Trichomonas, etc.Results: Of the 8 962 patients with STDs, the HIVseroprevalence in patients with and without GUD was1.75% (5/285) and 1.53% (133/8677), respectively,with no statistically significant difference (χ 2=0.09,P>0.05; OR=1.15, 95%CI=0.47-2.81) . HIVseroprevalence in patients with syphilis, genital her-pes and other STDs was 2.81% (22/784), 0.74% (6/814) and 1.49% (110/7 364), respectively. Prevalencein patients with syphilis was significantly higher thanthat in patients with genital herpes and other STDs,(χ 2=9.92, P<0.005, OR=3.89, 95%CI=1.67-9.05;χ 2=7.66, P<0.001, OR=1.90, 95%CI=1.21-3.00).Conclusions: The study shows that the HIV sero-prevalence in this population of patients with GUDis very low. The results also indicate an associationbetween syphilis and HIV infection. The relationshipbetween genital herpes and HIV infection needsfurther research.目的了解性病门诊生殖器溃疡性疾病(GUD)的HIV感染状况及其与HIV感染的关系。方法取GUD患者溃疡处分泌物进行暗视野显微镜检查、多重聚合酶链反应,同时取上述患者和非溃疡性性传播疾病(STD)患者尿道或宫颈或阴道分泌物进行淋球菌、沙眼衣原体、支原体、单纯疱疹病毒、人类乳头瘤病毒、念珠菌、滴虫及加特纳菌等检测;检测所有STD患者血清的HIV抗体及梅毒血清学试验。结果在8 962 例病人中,就诊时生殖器有溃疡的STD与生殖器无溃疡的STD病人中HIV 感染率分别为1.75% (5/285)和 1.53% (133/8677),两者无统计学意义(χ2=0.09, P>0.05; OR=1.15, 95% CI=0.47-2.81);梅毒、生殖器疱疹和其他STD病人的HIV感染率分别为2.81%(22/784)、0.74%(6/814)和1.49%(110/7 364),梅毒病人的 HIV 感染率明显高于生殖器疱疹和其他 STD 病人的 HIV 感染率,有统计学意义(2.81% vs 0.74%,χ2=9.92, P<0.005, OR=3.89, 95%CI=1.67-9.05; 2.81% vs 1.49%,χ2=7.66, P<0.001, OR=1.90, 95%CI=1.21-3.00)。结论本研究提示本组 GUD 病人 HIV 感染率较国外低,梅毒与 HIV 感染有明显相关性;生殖器疱疹病人与HIV 感染的关系尚待进一步研究。

关 键 词：genital ulcer sexually transmitteddisease HIV 

分 类 号：R759[医药卫生—皮肤病学与性病学]