依贝沙坦对高血压并心力衰竭患者心功能的影响  

The effect of irbesartan on cardiac function of heart failure in patients with hypertension

作　　者：常以芳[1] 闫玉真[1] 

机构地区：[1]山东省聊城市第二人民医院,252601

出　　处：《实用心脑肺血管病杂志》2004年第3期136-138,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

摘　　要：目的　观察血管紧张素Ⅱ受体阻滞剂依贝沙坦的降压疗效和对心功能的影响。　方法　试验组 (n=4 0 )口服依贝沙坦 1 5 0mg ,每日一次 ,连服 4周 ;对照组 (n =3 6 )口服卡托普利 1 2 5mg ,每日两次或三次 ,连服 4周 ,给药前后行超声心动图计算左室射血分数 (LVEF)和E A比值 ,评定心功能变化。用药期间进行体格检查及心电图观察。　结果　试验组收缩压 (SBP)和舒张压 (DBP)均明显下降 ,对照组改变不明显 ,组间比较差异非常显著 ;心功能的改善 ,试验组有效率为 80 %,对照组为 6 1 %,两组有效率有显著差异 ;LVEF的变化 :试验组由 0 41± 0 0 8升至0 48± 0 0 7(P <0 0 5 ) ,对照组由 0 40± 0 0 5升至 0 43± 0 0 4 (P >0 0 5 ) ;E A比值 :试验组由 0 5 7± 0 1 4升至 1 0 6± 0 1 3 (P <0 0 1 ) ,对照组由 0 5 7± 0 1 4升至 0 76± 0 1 2 (P <0 0 5 )。以试验组好转更为明显。　结论　依贝沙坦有利于缓解心衰症状 ,改善其收缩和舒张功能 ;其疗效优于卡托普利。Objective To observe the effect of irbesartan on cardiac function of heart failure in patients with hypertension Methods 76 hypertensive patients with CHF(congestive heart failure) were devided into two groups,to take oral irbesartan 72mg/d～100mg/d(n=40) for 4 weeks as the therapeutic group or captopril 12 5mg 2～3 times daily(n=36) for 4 weeks as the control group Before and after treatment the physical examination,ECG(electrocardiogram),EF(ejection fraction) and E/A ratio were performed and all the parameters were compared at last Results The SBP and DBP were significantly decreased in the therapeutic group but not in the control group The cardiac function were significantly improved in both groups,but the total effective rate in the therapeuntic group 80% was better than that in the control group 61% The LVEF and E/A ratio were also increase in both groups Conclusion Irbesarian could be to improve the cardiac function of CHF and its hypotensive effect is more better than captopril

关 键 词：依贝沙坦 高血压 心力衰竭 心功能 超声心动图 

分 类 号：R544.1[医药卫生—心血管疾病] R541.61[医药卫生—内科学]