冠心病患者血浆肿瘤坏死因子a及其受体的变化  

The change of Tumor necrosis factor a and its receptors in patients with coronary heart disease

作　　者：郭金玲[1] 张连凤[1] 王金良[1] 

机构地区：[1]天津市公安医院内科,天津300050

出　　处：《天津医科大学学报》2004年第2期173-174,共2页Journal of Tianjin Medical University

基　　金：天津市科学技术成果(登记号 :市20000215)

摘　　要：目的 :探讨冠心病患者血浆肿瘤坏死因子a(TNFa)和其受体含量的变化及其临床意义。方法 :检测69例冠心病患者和30例健康体检者 (正常对照组 )TNFa和其两种可溶性受体的含量。结果 :与正常对照组比较 ,冠心病患者 (SAP组和AMI组 )TNFa和其两种可溶性受体含量显著升高 (P<0.05) ;且AMI组TNFa水平显著高于SAP组。结论 :血浆TNFa及其可溶性受体与冠心病的发病和病情严重程度密切相关。Objective: To explore the change and clinical significance of Tumor necrosis factor a(TNFa) and its receptors. Methods:69 cases of coronary heart disease patients and 30 cases of healthy persons were examinated for the amount of TNFa and 2 kinds of its receptors.Results:Compared with the healthy control group,the amount of TNFa and its receptors were higher significantly in sera of coronary heart patient's group.The AMI group was greatly higher than that of SAP group. Conclusion:The TNFa and its receptors were closely associated with the incidence and severity of coronary heart disease.

关 键 词：肿瘤坏死因子a(TNFa) 肿瘤坏死因子受体(TNFR) 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]