天津市区慢性支气管炎急性发作患者不动杆菌感染的耐药性分析  

Analysis on antibiotic resistance of Acinetobacter from AECB patients in Tianjin

作　　者：韩金霞[1] 张菊英[1] 葛庚芝[1] 

机构地区：[1]天津医科大学第二医院呼吸科,天津300211

出　　处：《天津医科大学学报》2004年第2期243-245,共3页Journal of Tianjin Medical University

摘　　要：目的 :了解不动杆菌在慢性支气管炎急性发作患者中感染的细菌耐药性情况 ,以指导临床用药。方法 :将天津市区10所医院呼吸科收治的253例慢性支气管炎急性发作患者不动杆菌感染的结果进行耐药性分析。结果 :临床表现缺乏特异性。在检出的不动杆菌中鲍曼氏不动杆菌占第1位30.4% ,其余检出率依次为醋酸钙不动杆菌28.9%、洛非不动杆菌16.6 %、琼氏不动杆菌14.2 %、未分类9.9 %。药敏结果显示不动杆菌对亚胺培南耐药性最低为6.2%。其次为头孢他啶/舒巴坦10.6%、阿米卡星11.3 %、喹诺酮类耐药率为16.7% ,第3代头孢菌素中除头孢他啶/舒巴坦外的耐药率在17.4 %～34.0 % ,氨卞西林的耐药率最高53.6 % ,氨曲南的耐药率亦达到45.3 %。结论 :不动杆菌在慢性支气管炎急性发作患者中感染的临床表现无特异性 ,治疗时应根据药敏结果选择应用抗生素。Objective: To investigate the antibiotic resistance of Acinetobacter isolated from acute exacerbation of chronic bronchitis (AECB) patients in Tianjin.Methods: The clinical data and antibiotic resistance of 253 cases of AECB caused by Acinetobacter infection from respiratory department of 10 hospitals in Tianjin were reviewed.Results: Their clinical features were lack of specificity. In all isolates of Acinetobacter, isolations rates were as follows: Acinetobacter baumannii 30.4%, Acinetobacter calcoaceticus 28.7%, Acinetobacter lwoffii 16.6%, Acinetobacter junii 14.2%, and unclassified isolates 0.9%. The resistant rate of Acinetobacter to imipenem was the lowest (4.3%), followed by cefoperazone/sulbactam (10.6%), amikacin (11.3%),quinolone(16.7%), the other third generation cephalosporin (17.4%～34.0%), aztreonam (45.3%), while the resistant rate to ampicillin was the highest (53.6%). Conclusion: The clinical features of AECB caused by Acinetobacter infection has no specificity, so the antibiotic use should be selected according to the results of susceptibility testing.

关 键 词：不动杆菌 慢性支气管炎急性发作 耐药性 

分 类 号：R372[医药卫生—病原生物学]