格列齐特缓释片的制备及体外释放度  

Preparation and in vitro Dissolution of Gliclazide Sustained-release Tablets

作　　者：卢骏[1] 吴涛[2] 胡建平[1] 潘卫三[1] 

机构地区：[1]沈阳药科大学药学院药剂系,辽宁沈阳110016 [2]北京双鹤药业股份有限公司,北京100020

出　　处：《中国医药工业杂志》2004年第7期410-412,共3页Chinese Journal of Pharmaceuticals

摘　　要：选用两种黏度的羟丙甲纤维素为骨架材料和粘合剂,采用湿法制粒制备格列齐特缓释片;并与参比制剂比较体外释放行为。结果表明,所得片剂的体外释放符合一级动力学规律,释放曲线经f2(相似因子)判断,与参比制剂相似。The gliclazide sustained-release tablets were prepared by wetting granulation method using hydroxypropylmethyl cellulose with different viscosity as carrier and adhesive. The in vitro dissolution of the products was investigatedand compared with Diamicron MR. The results showed that both had the similar sustained-release property, and the drugrelease pattern was accorded with the first order kinetics.

关 键 词：格列齐特 缓释片 正交设计 体外释放 

分 类 号：R944.4[医药卫生—药剂学] R977.15[医药卫生—药学]