普罗帕酮与毛花苷丙治疗快速心房颤动的疗效比较  

FENOPRAINE AND LANATOSIDE C IN PATIENTS WITH ATRIAL FIBUILLATION AND CONGESTIVE HEART FAILURE

作　　者：霍永佳[1] 陈莺[1] 陈丽[1] 

机构地区：[1]遵义医学院第二附属医院内科

出　　处：《中国心血管病研究》2004年第7期520-522,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的　比较静脉应用普罗帕酮与毛花苷丙治疗快速心房颤动 (简称房颤 )并发充血性心力衰竭 (心衰 )患者心室率的即时效应及安全性。方法　 4 6例房颤患者 ,心室率≥ 12 0次 /min ,心功能Ⅱ级以上 (NYHA)。采用随机方法分组 ,分别静脉应用普罗帕酮与毛花苷丙。结果　普罗帕酮、毛花苷丙组控制房颤快速心室率的总有效率分别为81.0 %和 6 0 .9% (P <0 .0 5 ) ;心室率平均下降幅度分别为 35 %和 2 5 % (P <0 .0 1) ;平均起效时间分别为 (2 3.1±8.2 )min和 (5 0 .7± 10 .4 )min(P <0 .0 1)。普罗帕酮有 1例出现症状性低血压 ,1例出现第一度房室传导阻滞 ,无心衰加重表现。结论　静脉应用普罗帕酮能迅速、安全。Objective To evaluate the efficacy and safety of intravenous fenopraine and lanatoside C for the treatment of rapid ventricular rate in patients with atrial fibrillation and congestive heart failure. Methods 46 patients with rapid atrial fibrillation,ventricular rate more than 120 beats per minute, cardiac function more than the second grade(NYHA),were randomly divided into two groups. The two groups were intravenously administrated fenopraine and lanatoside C,respectively. Results The total efficacy on controlling rapid atrial fibrillation was 81.0% and 60.9% in fenoporaine group and lanatoside C groups,respectively.Ventricular rate decreased by 35% and 25%,respectively.The mean response time was (23.0±8.2) minutes and (50.7±10.4) minus, respectively.In fenopraine group,1 patients developed symptomatic hypotension,and 1 had the first degree atrioventricular conduct block without congestive heart failure worsening. Conclusion Fenoprsine is safe and rapid in the treatment of rapid ventricular rate in patients with atrial fibrillation and congestive heart failure.

关 键 词：普罗帕酮 毛花苷丙 心房颤动 心力衰竭 心室率 

分 类 号：R541.75[医药卫生—心血管疾病]