氯沙坦对心力衰竭患者肿瘤坏死因子α和血管内皮依赖性舒张功能的影响  

Effect of losartan on tumor necrosis factor-alpha and endothelial dependent diastolic function in patients with congestive heart failure

作　　者：李晓东[1] 孙亚清[1] 杨智勇[1] 曹乾[1] 

机构地区：[1]中国医科大学第二临床学院心内科,沈阳110004

出　　处：《中华心血管病杂志》2004年第6期519-521,共3页Chinese Journal of Cardiology

摘　　要：目的　观察氯沙坦对慢性心力衰竭 (chronicheartfailure ,CHF)患者肿瘤坏死因子α(TNF α)与血管内皮依赖性舒张功能 (endothelialdependentdiastolicfunction ,EDD)的影响。 方法测定 4 9例CHF患者 (CHF组 )和 38例无慢性心力衰竭患者 (无CHF组 )TNF α水平。 4 9例CHF患者随机分为氯沙坦组和常规治疗组。治疗前和治疗 4周后测定TNF α水平及用彩色多普勒血流仪测定肱动脉内径和反应性充血后的内径。结果　CHF组TNF α水平明显高于无CHF组 [( 10 7 4±4 7 2 )比 ( 76 2± 35 4 )ng/L ,P <0 0 1]。治疗 4周后 ,氯沙坦组TNF α水平比治疗前明显降低[( 10 8 5± 12 1)比 ( 91 3± 11 4 )ng/L ,P <0 0 5 ];而反应性充血后血管内径及其变化百分比明显升高 [( 4 9± 8 4 )比 ( 5 5± 7 7)mm ,P <0 0 5 ;( 2 9 2± 4 2 )比 ( 38 9± 5 9) % ,P <0 0 5 ];氯沙坦组的TNF α水平与反应性充血后血管内径及其变化百分比呈负相关 (r =- 0 5 2 ,P <0 0 5 ;r =- 0 6 4 ,P <0 0 5 )。结论　慢性心力衰竭患者的血管内皮功能受损 ,TNF α是引起这一损害的主要因素 ,氯沙坦治疗不仅可以控制心力衰竭症状 。Objective To observe the effect of short term treatment with losartan on tumor necrosis factor alpha (TNF α) and endothelial dependent diastolic function (EDD) in patients with chronic heart failure (CHF). Methods The levels of serum TNF α were measure in 49 patients with CHF in 39 patients without CHF. The CHF patients were randomized into losartan group ( n =25) and control group ( n =24). TNF α level and the baseline of brachial angiobore and its changes at response to reactive hyperemia were measure before and after treatment. Results The serum TNF α level in CHF patients was significantly higher than that in patients without CHF[(107 4±47 2) vs (76 2±35 4) ng/L, P <0 05]. Serum TNF α level was decreased after 4 weeks of treatment in losartan group [(91 3±11 4) vs (108 5±12 1) ng/L, P <0 05]. And the measurements of brachinal angiobore after reactive hyperemia were increased[(5 5±7 7) vs (4 9±8 4)mm, P <0 05; (38 9±5 9)vs (29 2±4 2)%, P <0 05], while these changes were significantly negatively correlated with TNF α level ( r =-0 52, P <0 05; r =-0 64, P <0 05). Conclusions The EDD in patients with CHF was damaged probably by TNF α. Losartan had obvious effect on the EDD of them, which was proved by the improved brachial EDD measurements and the symptoms of heart failure.

关 键 词：氯沙坦 心力衰竭 肿瘤坏死因子Α 血管内皮依赖性舒张功能 

分 类 号：R541.6[医药卫生—心血管疾病]