肝复康胶囊对实验性肝纤维化大鼠肝细胞的保护作用  

Protective Effect of Ganfukang Capsule on Hepatocytes in Rats with Experimental Hepatic Fibrosis

作　　者：车颖[1] 徐婷婷[2] 姜妙娜[2] 贾玉杰[2] 

机构地区：[1]大连医科大学附属第一医院,116011 [2]大连医科大学病生教研室,116027

出　　处：《中药材》2004年第6期428-429,共2页Journal of Chinese Medicinal Materials

摘　　要：目的 :探讨中药肝复康对实验性肝纤维化大鼠肝细胞的保护作用。方法 :采用四氯化碳致大鼠肝纤维化模型 ,观察肝复康对肝功能及肝细胞损伤超微结构的影响。结果 :肝复康明显改善肝细胞变性及炎细胞浸润等情况 ,同时明显降低血清转氨酶活性、升高血清白蛋白 ,降低白球蛋白比例 ;电镜观察表明肝复康对实验性肝纤维化大鼠肝细胞线粒体等细胞器的损伤有保护作用。结论 :肝复康能明显减轻四氯化碳所致的肝细胞损伤 ,保护肝细胞 ,改善肝功能。Objective: To observe the protective effect of Ganfukang Capsule on hepatocytes of rats with experimental hepatic fibrosis rat. Method: SD rat model of liver fibrosis was induced by CCl 4. The effect of Ganfukang Capsule on liver function, histological change and ultrastructural were examined. Results: Liver function, histological change and ultrastructural were significantly improved. The degree of steatosis was significantly decreased. Conlusion: Ganfukang Capsule might protect hepatocytes, mitochondria from the injury induced by CCl 4 and improve liver function.

关 键 词：肝复康胶囊 实验性肝纤维化 大鼠 肝细胞 保护作用 中药 

分 类 号：R285.5[医药卫生—中药学]