荔枝核拮抗2型糖尿病大鼠胰岛素抵抗作用的药理学机制  

Pharmacological Mechanism of Semen Litchi on Antagonizing Insulin Resistance in Rats with Type 2 Diabetes

作　　者：郭洁文[1] 李丽明[1] 潘竞锵 邱光清[3] 李爱华[3] 黄国华[3] 许莲好[3] 

机构地区：[1]广州市中医医院,广州510130 [2]广州市中医中药研究所,广州510130 [3]广东省药物研究所,广州510180

出　　处：《中药材》2004年第6期435-438,共4页Journal of Chinese Medicinal Materials

基　　金：广东省中医药局资助项目 (10 10 40 );广州市中医药;中西医结合资助项目 (2 0 0 110 )

摘　　要：目的 :研究荔枝核水提取物 (waterextractfromSemenLitchi ,以下简称荔枝核 )改善 2型糖尿病大鼠(T2DM)胰岛素抵抗 (IR)的药理学机制。方法 :采用T2DR IR模型 ,观察荔枝核对T2DM IR大鼠空腹血清血糖(FSG)、总胆固醇 (TC)、甘油三酯 (TG)、游离脂肪酸 (FFA)、血清尿素氮 (BUN)、肌酐 (Cr)、总蛋白 (TP)、白蛋白 (A)、丙二醛 (MDA)、瘦素 (leptin)、肿瘤坏死因子 α(TNF α)、胰岛素 (Fins)含量及胰岛素敏感指数 (ISI) ,以及丙氨酸氨基转移酶 (ALT)、天冬氨酸氨基转移酶 (AST)、超氧化物歧化酶 (SOD)活性等指标的影响。结果 :荔枝核能显著降低T2DM IR大鼠FSG、TC、TG、FFA、leptin和TNF α含量及高胰岛素血症 (P <0 0 5～ 0 0 1) ,显著提高ISI(P <0 0 1) ,增强胰岛素敏感性 ;加强SOD活性和降低MDA的含量 (P <0 0 1) ,增强抗氧化能力 ;降低ALT、AST活性和BUN、Cr含量 ,提高TP、A含量 (P <0 0 5～ 0 0 1) ,改善肝肾功能。结论 :荔枝核能调整T2DM IR大鼠Lept和TNF α含量及高胰岛素血症 ,拮抗IR ,改善胰岛素敏感性 ,调节糖脂代谢紊乱 ,增强抗氧化作用 。Objective:To investigate the pharmacological mechanism of Semen Litchi water extract (SL) on enhancing insulin sensitivity in type 2 diabetic rats (T2DR) with insulin resistance (IR).Methods:The effects of SL were observed on serum contents of fasting glucose (FSG),blood urea nitrogen (BUN),creatine (Cr),total proteins (TP),albumin (A),malondialdehyde (MDA),total cholesterols (TC),triacylglycerol (TG),free fatty acid (FFA),leptin,tumor necrosis factor-α (TNF-α),fasting insulin (Fins) and index of insulin sensitivity (ISI),and activities of superoxide dismutase (SOD),alanine aminotransferase (ALT),aspartate aminotransferase (AST) in T2DR-IR.Results:In T2DR-IR, SL could lower concentrations of FSG,TC,TG,FFA,leptin,TNF-α and Fins (P<0.05～0.01) ,increase ISI (P<0.01),reform the hyperinsulinemia and insulin sensitivity, decrease the levels of BUN,Cr and the activities of ALT,AST,increase concentration of TP,A (P<0.05～0.01),recover the hepatic and nephric functions, increase the activity of SOD and decrease content of MDA (P<0.01). Conclusion: SL could reduce the levels of TNF-α,hyper-leptinemia and hyperinsulinemia,antagonize insulin resistance,fortify insulin sensitivity,readjust lipodystrophy and maladjustment of glycometabolism,enhance antioxidation,and improve functions of liver and kidney in T2DR-IR.

关 键 词：荔枝核 2型糖尿病 大鼠 胰岛素抵抗作用 药理学 中药 

分 类 号：R259.871[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]