砂仁挥发油中乙酸龙脑酯镇痛抗炎作用的研究  

Studies on the Analgesic and Anti-inflammatory Effect of Bornyl Acetate in Volatile Oil from Amomum villosum

作　　者：吴晓松[1] 李晓光[2] 肖飞[2] 张志东[1] 徐珍霞[2] 王欢[2] 

机构地区：[1]暨南大学附属第一医院,广州510630 [2]暨南大学药学院,广州510632

出　　处：《中药材》2004年第6期438-439,共2页Journal of Chinese Medicinal Materials

基　　金：广东省中医药局科研资助项目 (10 2 0 42 )

摘　　要：目的 :研究砂仁挥发油主要成分乙酸龙脑酯的镇痛抗炎作用。方法 :小鼠热板致痛实验 ,冰醋酸致小鼠疼痛实验 ,二甲苯致小鼠耳廓肿胀实验。结果 :乙酸龙脑酯高剂量组对小鼠热板致痛的痛阈值有一定程度的提高 ;对小鼠醋酸致痛引起的扭体次数有明显的降低作用 ;能抑制二甲苯致小鼠耳廓肿胀炎症。结论Objective:To study analgesic and anti-inflammatory effects of bornyl acetate,the main ingredient of Amomum villosum volatile oil.Methods:The analgesic effects were tested by hot-plate and writhing reaction method,the ear swelling caused by dimethylbenzene in mice. Results:Bornyl acetate could restrain writhing reaction caused by acetic acid glacial,lighten the pain caused by hot-plate. It could also suppress ear swelling caused by dimethylbenzene in mice.Conclusion:Bornyl acetate shows analgesic and anti-inflammatory effects.

关 键 词：砂仁挥发油 乙酸龙脑酯 镇痛作用 抗炎作用 

分 类 号：R285.5[医药卫生—中药学]