妊娠高血压综合征患者胎盘组织中TGFβ1的表达及意义  

Expression and Significance of TGF-β_1 in the Placenta of Patients with Pregnancy-induced Hypertention

作　　者：康德凡[1] 尚丽新[1] 曲冬颖[1] 姜彦多[2] 王继红[2] 

机构地区：[1]解放军第二0二医院妇产科,辽宁沈阳110003 [2]解放军第二0二医院病理科,辽宁沈阳110003

出　　处：《中国医师杂志》2004年第7期889-891,共3页Journal of Chinese Physician

摘　　要：目的　探讨转化生长因子 β1(TGFβ1)在妊高征患者胎盘组织中的表达及其临床意义。 方法　采用免疫组化SABC法检测 64例妊高征患者 (轻度 2 1例 ,中度 2 0例 ,重度 2 3例 )胎盘组织中TGFβ1的表达 ,2 0例正常孕妇为对照组。 结果　⑴TGFβ1主要表达于胎盘绒毛滋养细胞及蜕膜细胞。⑵妊高征患者胎盘绒毛滋养细胞及蜕膜细胞TGFβ1的表达均明显增高 ,且随病情严重程度的增加而升高。⑶妊高征患者胎盘重量及新生儿体重与胎盘组织TGFβ1呈明显负相关。 结论　胎盘TGFβ1升高引起滋养细胞浸润不足 ,可能是妊高征的发病因素之一。Objective To study expression and clinical significance of TGF-β 1 in the placenta of the patients with pregnancy-induced hypertension(PIH). Methods The SABC immunohistochemical method was performed to determine the location and intensity of TGF-β 1 expression in placental tissues of 64 patients with PIH and 20 normal pregnant women. Results TGF-β 1 expression was principally localized in the trophoblast and decidual cells. The expression level of TGF-β 1 in the trophoblasts and decidual cells significantly increased in the patients with PIH compared with the normal pregnant women, and elevated with the severity of PIH increased. A negative relation was found between the expression level of TGF-β 1 and the weight of placenta and neonate in the patients with PIH. Conclusion The elevated expression of TGF-β 1 in placenta leads to the deficiency of trophoblast cell invasion, which may be one of the pathogenic causes of PIH.

关 键 词：妊娠高血压综合征 胎盘组织 TGFΒ1 基因表达 免疫组化 

分 类 号：R714.246[医药卫生—妇产科学]