子宫颈蓝痣的病理学和免疫组织化学观察  

PATHOLOGICAL AND IMMUNOHISTOCHEMICIAL STUDIES OF THE BLUE NEVUS OF THE UTERINE CERVIX

作　　者：赵兰[1] 卢德宏[1] 徐庆中[1] 杨虹[1] 贺志立[1] 

机构地区：[1]首都医科大学宣武医院病理科,北京100053

出　　处：《河北医科大学学报》2004年第4期203-205,F003,共4页Journal of Hebei Medical University

摘　　要：目的探讨宫颈蓝痣的临床病理特点及发生起源。方法因子宫平滑肌瘤行子宫全切 ,其中 9例宫颈管内有直径 3～ 5mm黑褐色斑者 ,进行光学显微镜观察及免疫组织化学染色。结果光镜下见宫颈管基质中分布有胞质 ,内含有褐色色素的细胞 ;Masson Fontana法染色呈黑色 ,S 1 0 0蛋白和人类黑色素瘤相关抗原呈阳性表达。结论宫颈蓝痣是一种发生在皮肤以外的少见色素性病变 ,推测痣细胞是由于神经嵴细胞迁移过程中的滞留并增生所致。ObjectiveThe purpose of this study is to explore the clinical and pathological features and the possible origin of the blue nevus of the uterine cervix. MethodsThe hysterectomy specimens were taken from uterus which had been surgically excised for uterine leiomyoma of women. Pigmented macules with dimension of 3 mm to 5 mm can be seen in the canalis cervices uteri of the nine cases. Light microscopic examination and immunohistochemicial studies had been performed. ResultsThere are melanin containing cells distributed in the stroma of the canalis cervices uteri; Masson Fontana stained as black while S 100 protein and HMB45 present as positive. ConclusionThe blue nevus of the uterine cervix is a rare kind of extra cutaneous pigmented lesions, which is assumed to be caused by the proliferation of melanocytes arrested in an ectopic area during migration from the neural crest towards the final destination.

关 键 词：子宫颈 痣 蓝 病理学 免疫组织化学 

分 类 号：R711.74[医药卫生—妇产科学]