颅脑火器伤早期脑微血管三维构型和超微结构实验研究  

Three-dimensional architecture and ultrastructure of the cerebral microvasculature of missile brain wound in cats

作　　者：钱畅 陈长才[2] 

机构地区：[1]桂林市人民医院神经外科,广西桂林541002 [2]第一军医大学珠江医院神经外科,广东广州510282

出　　处：《第一军医大学学报》2004年第7期765-767,共3页Journal of First Military Medical University

基　　金：军队九五军事医学科研课题(98M067)~~

摘　　要：目的 探讨颅脑火器伤早期猫脑微血管三维构型和超微结构变化。方法 应用脑微血管铸型扫描电镜观察伤后脑微血管三维结构的变化,同时行脑超薄切片透射电镜观察微血管内皮细胞和神经细胞结构的变化。结果 颅脑火器伤后,脑微血管发生紊乱,既有血管痉挛又有血管扩张,出血和缺血并存,微血管括约肌出现病理性强力收缩,部分微血管破裂,血管内皮细胞微绒毛、空泡增多,紧密连接增宽,基底膜断裂,血管周围水肿及周围神经细胞损伤。结论 颅脑火器伤早期脑微血管结构出现损害,引起了脑微循环功能紊乱,导致脑的继发性损害。Objective To explore the changes of cerebral microvasculature in cats with missile brain wound. Methods The microvascular corrosion casts of the brain were examined by scanning electron microscopy, and the ultra-thin slices of the brain were inspected by transmission electron microscopy. Results The brain microvasculature showed evidently abnormal morpholo- gical changes, with both vasospasm and vasodilation as well as concurrent bleeding and ischemia. Strong pathological contraction of vascular sphincter, rupture of some microvessels, and increased microvilli and vacuoles in the endothelial cells were observed. Loosening of the intercellular tight junction and basal membrane rupture occurred along with perivascular swelling and neural cell damages. Conclusion Morphological or functional changes occur in the cerebral microvasculature leading to secondary brain injury after missile brain wound in cats.

关 键 词：颅脑火器伤 微血管铸型 三维构型 超微结构 

分 类 号：R651.1[医药卫生—外科学]