滋补脾阴方药治疗大鼠脊髓损伤实验研究  

Experimental study of nourishing Piyin Remedy on rat with spinal cord injury

作　　者：王鸿飞[1] 富灵杰[2] 战丽彬[1] 郑连杰[1] 刘用楫[1] 苗艳颖[3] 

机构地区：[1]大连医科大学第二附属医院骨科,辽宁大连市116023 [2]大连医科大学2001级研究生班,辽宁大连市116023 [3]北京大学医学部,北京市100000

出　　处：《中国康复理论与实践》2004年第6期343-345,共3页Chinese Journal of Rehabilitation Theory and Practice

基　　金：国家教委留学回国人员科研课题 (0 2 0 0 4 )

摘　　要：目的探讨滋补脾阴方药对实验性大鼠脊髓损伤的作用和机理。方法 3 2只健康SD大鼠随机分为滋补脾阴方药组和损伤组 ,采用改良Allen氏装置建立大鼠T8—T9节段脊髓不完全性损伤动物模型。通过脊髓神经功能、体感诱发电位、辣根过氧化酶示踪、大体观察、组织学及超微结构等检查 ,对比两组动物的差异。结果与损伤组相比 ,滋补脾阴方药组大鼠的脊髓神经功能评分、体感诱发电位、脊髓运输能力、大体观察、组织形态计量分析、髓鞘和神经元细胞结构等皆有明显改善。结论滋补脾阴方药能明显阻止脊髓的继发性损伤 ,促进脊髓损伤大鼠神经功能的恢复。ObjectiveTo study the therapeutic effect and mechanisms of nourishing Piyin Remedy (nPR) on experimental rat spinal cord injury.MethodsThirty-two healthy SD rats were divided into 2 equal groups randomly: nPR group and injured group. Animal model of incomplete injury of spinal cord was made by Allen's equipment on rat's T 8—T 9 segment. The spinal nerve function,SEP,retrograde and label technique of horse radish peroxidase,gross observation,histological and morphometric analysis were taken as the observed indices.ResultsThe value of observed indices of nPR group were improved evidently compared with injured group.ConclusionNourishing Piyin Remede can hold back the secondary spinal cord injury and accelerate the recovery of spinal nerve function.

关 键 词：脊髓损伤 滋补脾阴方药 大鼠 

分 类 号：R651.2[医药卫生—外科学]