铅对儿童骨代谢的影响  

Influence of lead on bone metabolism of preschool children

作　　者：石凯丽[1] 马宏[2] 王文英[2] 张会丰[3] 原平飞[2] 

机构地区：[1]山西省儿童医院,山西太原030001 [2]山西医科大学第一临床医学院儿科,山西太原030001 [3]河北医科大学第二医科儿科,河北石家庄050000

出　　处：《中国儿童保健杂志》2004年第2期109-111,共3页Chinese Journal of Child Health Care

基　　金：山西省卫生科技发展计划项目 (2 0 0 2 0 6)

摘　　要：【目的】　通过对山西省某铅污染较重矿区儿童血铅水平及骨代谢生化指标的测定 ,探讨血铅对儿童骨代谢的影响。　【方法】　整群抽取 5～ 6岁儿童 12 0名 ,应用石墨炉原子吸收光谱法测定血铅值 ;通过酶联免疫法(ELISA)检测本组儿童血清骨钙素 (OC)、骨碱性磷酸酶 (BALP)及 2 5 (OH)D3 水平。　【结果】　随着血铅水平的增高 ,该组儿童的血清OC和 2 5 (OH)D3 水平呈下降趋势 ,而BALP呈上升趋势。其中Ⅲ级铅中毒儿童血清OC较Ⅰ级铅中毒儿童显著下降 (P <0 .0 1) ,而血清BALP显著增高 (P <0 .0 1) ,且Ⅱ级铅中毒儿童血清BALP较Ⅰ级铅中毒儿童已有显著增高改变 (P <0 .0 1)。另外 ,相关性分析表明本调查组儿童血铅水平与OC和 2 5 (OH )D3 呈负相关而与BALP呈正相关。　【结论】　铅中毒可抑制成骨细胞的活动 。To investigate the influence of lead on bone metabolism of children among a mine contaminated with lead in Shanxi. The blood lead level was measured by method of graphite furnace atomic absorption apectrometry and the serum osteocalcin(OC),bone alkaline phosphatase(BALP),25 hydroxy vitamin D 3 [25 (OH)D 3] were also measured in a population of 120 preschool children aged 5～6 years who were from the mine kindergarten. With the increasing of blood lead level the serum OC and 25 (OH)D 3 had the tendency of decline but the BALP had the tendency of increasing.Children whose blood lead level were the grade Ⅲ had lower serum OC ( P <0.01),but higher serum BALP( P <0.01),than those whose blood lead level were the grade Ⅰ, moreover, children with grade Ⅱ lead level already had higher serum BALP( P <0.01) than those with grade Ⅰ level.And the research proved for these children, blood lead level had negative correlation with serum OC and 25 (OH)D 3 but positive correlation with BALP. [Conclusion] Lead poisoning can influence the function of osteoblast and inhibit the degrees of bone mineralization of the children.

关 键 词：铅中毒 骨钙素 骨碱性磷酸酶 25羟维生素D3 儿童 

分 类 号：R179[医药卫生—妇幼卫生保健]