干姜提取物对兔急性心衰模型的保护和治疗作用  

Preventive and Thearapeutic Effects of Ginger Extraction on Rabbits with Acute Heart Failure

作　　者：许庆文[1] 卢传坚[1] 欧明[1] 王宁生[1] 宓穗卿[1] 

机构地区：[1]广州中医药大学临床药理研究所,广州510405

出　　处：《中药新药与临床药理》2004年第4期244-247,共4页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的探讨干姜提取物对兔心衰模型是否有保护和治疗作用。方法将纯种新西兰兔随机分为观察组(造模前后均灌服2%干姜提取物)、对照组(造模前灌服蒸馏水,造模后灌服2%干姜提取物)和空白组(造模前后均灌服蒸馏水)3组,观察各组造模所需时间和所需戊巴比妥钠用量;测定造模前后兔的血流动力学指标。结果(1)干姜提取物能使戊巴比妥钠所致兔急性心力衰竭模型形成所需的时间和造模剂用量明显增加,与对照组和空白组相比较,差异有显著性意义(P<0.01);(2)各组指标用药后有回升趋势,但速度与程度有所不同,并且随着时间的推移,上升趋势的差异渐趋明显。血流动力学指标lv±dp/dtmax、lv+dp/dtmax、lv-dp/dtmax明显改善,lv±dp/dtmax、lv+dp/dtmax、lv-dp/dtmax在药后45min开始,组间差异有显著性意义(P<0.05或0.01);LVSP升高,t-dp/dtmax缩短,LVSP和t-dp/dtmax分别在药后60min和90min才开始显示组间差异(P<0.05)。结论干姜提取物对兔急性心力衰竭模型形成具有保护作用;能通过改善心室舒缩功能,降低外周阻力,改善心衰程度,对急性心力衰竭具有实验性治疗作用。Objective To investigate the preventive and therapeutic effects of Ginger extraction on heart failure in rabbits.Methods Twenty-seven New Zealand pure-breed rabbits were randomized into 3 groups:group A,group B and group C.Group A was orally administrated with 2 %Ginger extraction 3 days before and after modeling;group B was orally administrated with purified water 3 days before modeling and with 2 %Ginger extraction after modeling;group C was orally administrated with purified water 3 days before and after the establishment.The differences of modeling time and dosage of pentobarbital sodium between groups were compared;hemodynamics parameters before and after administration were detected.Results (1)The modeling time and dosage of Pentobarbital Sodium were remarkably increased in group A,differences being significant compared other 2 groups(P < 0.01);(2)all the hemodynamics indications showed a recovering trend in 3 groups at different rates and to different extent.The recovering trend increased with administration time.Differences of lv±dp/dtmax,lv+dp/dtmax and lv-dp/dtmax between groups were significant 45 minutes after administration(P < 0.05 or P < 0.01);LVSP was increased and t-dp/dtmax shortened,the differences of LVSP being significant 60 minutes after administration and that of t-dp/dtmax being significant 90 minutes after administration(P < 0.05).Conclusion Ginger extraction has preventive effect on acute heart failure;it exerts certain therapeutic effect on acute heart failure by enhancing the cardiac systolic/diastolic function and by reducing peripheral resistance.

关 键 词：干姜提取物 戊巴比妥钠 心力衰竭 动物模型 血流动力学 

分 类 号：R285.5[医药卫生—中药学]