二苯乙烯苷对痴呆小鼠学习记忆及大脑炎性反应的影响  

Effects of Stilbene-glycoside on Learning and Memory and Inflammatory Reaction of Brain in Dementia Mice

作　　者：楚晋[1] 叶翠飞[1] 李林[1] 

机构地区：[1]首都医科大学宣武医院药理研究室,北京脑老化重点实验室北京100053

出　　处：《中药新药与临床药理》2004年第4期235-237,共3页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家重点基础研究发展计划-"973"项目(编号G2000057010);北京市自然科学基金项目(编号7982006);北京市科委资助北京市重点科技实验室项目(编号951890600);首都二四八重大创新工程项目(编号H010210130113);北京市中医药重点学科项目(编号2001);首都

摘　　要：目的观察二苯乙烯苷(TSG)对β-淀粉样肽致痴呆模型小鼠学习记忆及炎性反应的影响。方法向小鼠右侧脑室定向注射Aβ1-40建立痴呆模型,并以TSG灌胃预防给药,各组小鼠均作Morris水迷宫及避暗等行为学测试,然后采用放免法对脑皮层白介素-6(IL-6)含量进行测定。结果与对照组相比,模型组小鼠学习记忆能力明显降低,皮层IL-6含量明显升高;与模型组相比,TSG组小鼠学习记忆能力明显提高,皮层IL-6含量明显降低。结论TSG能明显提高学习记忆能力,降低皮层IL-6含量,对AD的防治具有良好的应用前景。Objective To observe the effect of 2,3,5,4'-tetrahydroxy stilbene-2-β-D-glycoside (TSG)on learning and memory and free radicals metabolism in mice with dementia induced by β-amyloid(Aβ).Methods The mice models were established by injection of Aβ1-40 into the right lateral ventricle,and the treatment group was administered with TSG for 8 weeks by gastrogavage.Morris water maze and step-through test were performed in all the mice and then the mice were killed and radioimmunoassay was used to detect the content of interleukin-6(IL-6).Results The learning and memory in model mice were worse and the cortical IL-6 content increased compared to the normal control mice.TSG improved the learning and memory of Aβ-induced model mice and reduced cortical IL-6 content.Conclusion TSG could improve the learning and memory of dementia mice and decrease cortical IL-6 content,indicating a promising prospect in the treatment of dementia disease such as Alzheimer's disease.

关 键 词：二苯乙烯苷 Β-淀粉样肽 痴呆 学习记忆 阿尔茨海默病 

分 类 号：R285.5[医药卫生—中药学]