极低出生体重儿脑室内出血危险因素病例对照研究  

A Case-control Study on Risk Factors of Intraventricular Hemorrhage in the Very Low Birth Weight Infants

作　　者：袁天明[1] 顾美虹[1] 

机构地区：[1]浙江大学医学院附属儿童医院,浙江杭州310003

出　　处：《浙江预防医学》2004年第8期9-10,12,共3页Zhejiang Journal of Preventive Medicine

摘　　要：目的　探讨极低出生体重儿脑室内出血 (IVH)的临床特点和危险因素。方法　对新生儿重症监护病房 48例并发IVH的极低出生体重儿与同期住院治疗、曾经头颅B超检查的 77例极低出生体重儿进行回顾性对照分析。比较两组患者的临床特点 ,采用非条件Logistic回归进行多因素分析并计算OR值及OR的95 %可信限 ( 95 %CI)。结果　极低出生体重儿IVH的发病率为 3 8 4%。多因素非条件Logistic回归分析显示 :围产期窒息 (OR =6 3 79,95 %CI=1 192～ 3 4 14 4)、机械通气时间 (OR =8 3 74,95 %CI=2 5 61～ 2 7 3 88)和苯巴比妥治疗 (OR =0 0 81,95 %CI=0 0 2 3～ 0 2 68)为极低出生体重IVH的独立相关因素。结论　IVH在早产儿中发生率高 ,围产期窒息、机械通气时间和苯巴比妥治疗与极低出生体重儿IVH的发生有密切关系。Objective To identify the clinical characteristics and risk factors of intraventricular hemorrhage (IVH) in the very low birth weight infants. Methods A case-control study was conducted in 125 very low birth weight (VLBW) infants. The case group was those neonates with IVH, and the control group was those without IVH. Non-conditional logistic regression analysis was performed to determine the risk factors for IVH. The odds ratios (OR) and their 95% confidence intervals (95%CI) were estimated. Results The incidence rate of intraventricular hemorrhage was 38.4% in VLBW infants. By non-conditional logistic regression analysis, perinatal asphyxia (OR=6.379, 95% CI=1.192～34.144), duration of mechanical ventilation (OR=8.374, 95% CI=2.561～27.388), treatment with phenobarbital (OR=0.081; 95% CI=0.023～0.268) were significantly associated with IVH independently. Conclusions Perinatal asphyxia, duration of mechanical ventilation and treatment with phenobarbital are significantly correlated with the occurrence of IVH in VLBW infants.

关 键 词：极低出生体重儿 脑室内出血 IVH 危险因素 后遗症 

分 类 号：R722.151[医药卫生—儿科]