子宫内膜异位症的子宫内膜雌激素受体和孕激素受体mRNAs的表达  

The expression of ER and PR mRNAs in endometrium with endometriosis

作　　者：郑辉[1] 李洪义[2] 宇丽[3] 王自能[4] 金海燕[4] 王跃春[1] 

机构地区：[1]暨南大学医学院生理教研室,广东广州510632 [2]中山大学中山医学院,广东广州510089 [3]暨南大学医学院生化教研室,广东广州510632 [4]暨南大学医学院妇产科教研室,广东广州510632

出　　处：《暨南大学学报（自然科学与医学版）》2004年第4期441-445,共5页Journal of Jinan University(Natural Science & Medicine Edition)

摘　　要：目的 :探讨雌激素受体 (ER)和孕激素受体 (PR)在子宫内膜异位症 (内异症 )子宫内膜的表达。方法 :利用大鼠内异症动物模型 ,采用逆转录聚合酶链反应 (RT -PCR)技术 ,检测子宫内膜ER和PRmRNAs的表达情况。结果 :内异症模型组大鼠异位内膜ER、PRmRNAs的表达低于在位内膜和对照组正常子宫内膜 ,与后两者比较差异有显著性意义 (P <0 0 1) ;而模型组在位内膜ER、PRmRNAs的表达与正常对照组比较差异无显著性意义 (P >0 0 5 )。内异症模型组异位内膜ER/PRmRNA大于在位内膜和正常子宫内膜ER/PRmRNA(P <0 0 1)。结论To explore the expression of ER and PR mRNAs in endometrium with endometriosis. Methods: The rat model of endometriosis was established, and the expression of ER and PR mRNAs in the endometrium was examined by reverse transcription-polymerase chain reaction (RT-PCR). Results: The expression of ER and PR mRNAs in ectopic endometrium was significantly lower than that in eutopic and normal endometrium (P<0.01). But no difference was observed between eutopic and normal endometium (P<0.05). Ratio of ER / PR mRNA in ectopic endometrium was larger than that in eutopic and in normal endometrium (P<0.01). Conclusion:The result illuminates that the increased ER plays a vital role in the onset of endometriosis.

关 键 词：子宫内膜异位症 子宫内膜 雌激素受体 孕激素受体 

分 类 号：R339.2[医药卫生—人体生理学]