乌司他丁治疗急性胰腺炎的临床疗效评价  

Clinical evaluation of efficacy of ulinastatin in treatment of patients with acute pancreatitis

作　　者：曾连山[1] 陈念平[1] 林木生[1] 莫艾[1] 周宇[2] 黄存林 

机构地区：[1]广东医学院附属医院普外科 [2]广东医学院附属医院消化内科 [3]湛江南油医院外科

出　　处：《中国临床药理学与治疗学》2004年第7期828-830,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的 :观察乌司他丁 (UTI)治疗各型急性胰腺炎 (AP)的临床疗效。方法 :将 10 2例急性胰腺炎患者随机分成 2组 ,对照组 5 1例 (轻症 38例、重症I型13例 ) ;治疗组 5 1例 (轻症 38例、重症I型 13例 )。对照组采用综合基础治疗 ,治疗组在综合基础治疗的基础上加用乌司他丁。按痊愈、显效、有效和无效四级评定疗效。结果 :治疗组轻症有效率为92 .1% ,重症I型为 84 .6 % ;对照组轻症有效率为71.1% ,重症I型为 38.5 % ,两组有显著差异性 (P<0 .0 5 ) ,治疗组对腹痛、血尿淀粉酶、白细胞和TB等的恢复明显优于对照组 (P <0 .0 5 )。结论 :乌司他丁用于治疗急性水肿型胰腺炎和重症I型均有较好疗效 。AIM: To observe the clinical effects of ulinasta-tin (UTI) in treatment of patients with acute pancreatitis (AP). METHODS: 102 patients with acute pancreatitis were randomly divided into two groups. There were 51 cases (38 cases of light type, 13 cases of severe type I) in control group, which were given conventional treatment. There were 51 cases (38 cases of light type, 13 cases of severe type I) in treatment group, which were given conventional treatment and UTI. Clinical results were assessed as cured, significant effective, effective and non-effective. RESULTS: The effective rate was 92.1% in light type, 84.6% in severe type I in treatment group, while the effective rate was 71.1% in light type, and 38.5% in severe type I in control group (P< 0.05). The therapeutic effects in treatment group were better than those of in control group (P< 0.05) for releasing abdominal distention, amylase, white blood cells and TB. CONCLUSION: UTI is an effective agents in treating AP (light type and severe type I) with fewer side effects.

关 键 词：乌司他丁 急性胰腺炎 治疗 药效学 随机对照研究 

分 类 号：R969.4[医药卫生—药理学]