大鼠内侧隔核对齿状回习得性LTP的调制  

THE MODULATION OF MEDIAL SEPTAL NUCLEUSON LEARNING-DEPENDENT LONG-TERMPOTENTIATION IN THE RATDENTATE GYRUS

作　　者：陈燕勤[1] 许世彤[1] 区英琦 

机构地区：[1]华南师范大学神经生理研究室,广州510631

出　　处：《Zoological Research》1993年第4期335-340,共6页动物学研究（英文）

基　　金：国家自然科学基金

摘　　要：本工作观察到高频刺激(High—frequency stimulation、HFS)自由活动的大鼠内侧隔核(MedialSeptal nucleus,MS),对海马齿状回(dentate gyrus,DG)的群体峰电位(Population spike,PS)有一时性1—2h)的抑制作用。在明暗辨别学习中每次训练作业后立即给予MS HFS,导致DG习得性长时程增强,(Long—term potentiation,LTP)的形成显著延缓,并且PS峰值增强的最高水平显著降低(P<0.001),辨别反应的习得相应延迟,但对DG习得性LTP的保持无影响。表明MS对DG习得性LTP的形成有抑制性作用。提示这可能是隔区参与学习和记忆的机制之一。Population Spike (PS) elicited by perforant path stimulation in the dentate gyrus (DG) of freely moving rats was recorded. Rats were trained on discrimination learning. The results were as follows: (1) High- frequency stimulation (HFS) of the medial septal nucleus (MS) temporarily caused a suppression of PS in DG; (2) HFS of MS following daily training session caused a significant suppression of the development of learning-dependent long-term potentiation (LDLTP), and correspondingly, a prevention of the acquisition of discriminative responding; (3) HFS of MS resulted in a significant decrease (P<0. 01) of the maximal level of the potentiation of PS amplitude. These results suggest that MS exerts an inhibitory modulated effects on LDLTP in DG, which mainly affects the development of LDLTP.

关 键 词：长时程增强 学习 记忆 齿状回 鼠科 

分 类 号：Q959.837[生物学—动物学]