幽门螺杆菌HSP60、CagA抗体水平与消化性溃疡的相关性  

The levels of the Helicobacter pylori antibodies of HSP60 and CagA and their relation with peptic ulcer

作　　者：张萍[1] 刘艳萍[1] 王明月[1] 孔春妍[1] 

机构地区：[1]济南铁路中心医院儿科,山东济南250001

出　　处：《实用医药杂志》2004年第6期539-540,共2页Practical Journal of Medicine & Pharmacy

摘　　要：目的探讨幽门螺杆菌(HP)HSP60、CagA抗体检测的临床意义。方法采用HelicoStick法进行末梢血幽门螺杆菌HSP60、CagA抗体检测。结果7～18岁儿童HP抗体总阳性率为14.72%,HSP-60IgG阳性率13.88%,CagAIgG阳性率6.19%。除10～12岁组的HP抗体阳性率最低外,HP抗体阳性率随年龄增长而逐渐升高,但无统计学意义。健康儿童组、慢性胃炎组、消化性溃疡组HP抗体阳性率逐渐增高,差异有统计学意义。CagA-IgG阳性率消化性溃疡组明显高于健康儿童与慢性胃炎组,差异有统计学意义。结论CagA-IgG阳性可作为诊断消化性溃疡合并HP感染的依据。HelicoStick法检测幽门螺杆菌抗体,快速、简洁、高效。Objective To investigate clinical significance of Helicobacter pylori (HP) antibodies of HSP60 and CagA. Methods The antibodies of HSP60 and CagA were detected by Helio Stick method. Results The total prevalence of anti-H of children (aged from 7-18 year) was 14.72%, HSP60-IgG was 13.88% and CagA-IgG was 6.19%. An age-related increase of prevalence was shown for anti-H, except the 10-12 year-group. But the difference had no statistical significance. There was an increased tendency during healthy group, chronic gastritis group and peptic ulcer group,and the results showed a statistical significance. The prevalence of CagA-IgG peptic ulcer group was higher than that of healthy and chronic gastritis group.The results showed a statistical significance. Conclusion The prevalence of CagA-IgG can be taken as diagnosis mark of peptic ulcer patients who had be HP infection.The HP antibodies detected by Helio Stick method is convenient and efficient. This method should be taken spreading.

关 键 词：幽门螺杆菌 抗体检测 消化性溃疡 HSP60 CAGA 

分 类 号：R378.2[医药卫生—病原生物学] R573.1[医药卫生—基础医学]