δ-氨基-γ-酮戊酸脱水酶基因多态性与铅毒性的遗传易感性  

δ-Amino-γ-levulinic acid dehydrase (ALAD) gene polymorphism and susceptibility to lead toxicity

作　　者：黄瑞雪[1] 黄德群 

机构地区：[1]中南大学湘雅医学院公共卫生学院,湖南长沙410078 [2]湖南省株洲市第一医院,湖南株洲412000

出　　处：《中国工业医学杂志》2004年第3期179-180,187,共3页Chinese Journal of Industrial Medicine

摘　　要：δ 氨基 γ 酮戊酸脱水酶 (ALAD)是参与血红素生物合成的关键酶之一 ,可催化两分子的δ 氨基 γ 酮戊酸(ALA)聚合成卟胆原 (PBG)。有研究表明 ,ALAD基因多态性与铅中毒的易感性相关 ,分布存在种族差异 ,其等位基因ALAD1个体骨铅含量高 ,ALAD2个体血铅值较高。The δ-amino-γ-levulinic acid dehydrase(ALAD)gene is located in chromosome 9q34,coded for δ-aminolevulinic acid dehydratase(ALAD).ALAD is one of crucial enzymes involved in bio-synthesis of heme,which can catalyze two molecules of ALA to polymerize into a porphobilinogen(PBG).ALAD gene is polymorphic with two codominant alleles ALAD1 and ALAD2.Gene polymorphism of ALAD relates with susceptibility to lead toxicity and its genotype frequencies vary by race.Bone lead content is higher in the individuals with ALAD1 allele,and blood level of lead higher in those with ALAD2 allele.Research progress in ALAD gene polymorphism and susceptibility to lead toxicity is reviewed in this paper.

关 键 词：δ-氨基-γ-酮戊酸脱水酶(ALAO)基因 基因多态性 铅毒性 易感性 

分 类 号：R995[医药卫生—毒理学]