组蛋白密码  

Histone Code

作　　者：李珺[1] 薛丽香[1] 张宗玉[1] 童坦君[1] 

机构地区：[1]北京大学医学部生物化学与分子生物学系,北京市100083

出　　处：《医学分子生物学杂志》2004年第2期100-103,共4页Journal of Medical Molecular Biology

基　　金：国家重点基础研究发展规划(G2000057001);国家自然科学基金(30271432;30371561)

摘　　要：遗传信息的传递是从核酸序列三联密码子的转录和翻译,到合成具有完整结构的功能蛋白质的全过程。随着对遗传信息库的认识越来越深入,人们发现基因组DNA是非遗传信息库的唯一决定因素。晚近,有作者提出“组蛋白密码”学说,使组蛋白的研究倍受瞩目。该学说表明,组蛋白氨基末端的多样化修饰扩充了遗传密码的信息库。The whole process of genetic information regulation and transduction involves three major steps: transcription and translation of the genetic code and the synthesis of the functional protein. With better understanding of genetic coding, it has been found that DNA is not solely responsible for the generation the full range of information that results in a complex eukaryotic organism, such as human beings. Recently, Strahl and Allis's proposition of the existence of 'histone code' makes the investigation of histone a heated field. The theory believes that a diverse array of covalent modifications that largely impinge on histone amino termini, such as acetylation, phosphoration, methylation and so on, may considerably extend the information potential of genetic (DNA) code. This article reviews the advances in this field.

关 键 词：组蛋白密码 乙酰化 去乙酰化 甲基化 

分 类 号：Q342[生物学—遗传学]