低分子肝素治疗前后对肾病患者纤维蛋白单体聚合功能和D-二聚体改变  

The changes of fibrin monomer polymerization function and D-dmer in nephrotis patients before and afterr the treatment with low molecule heparin treatment

作　　者：刘燕婕[1] 罗顺德[2] 丁虹[2] 

机构地区：[1]华中科技大学协和医院,湖北武汉430022 [2]武汉大学药学院,湖北武汉430072

出　　处：《中国医院药学杂志》2004年第7期406-408,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的 :探讨纤维蛋白单体聚合功能 (FMPF)和D 二聚体 (D D)在抗凝治疗疗效观察中的意义。方法 :用纤维蛋白单体聚合动力学检测法和酶联免疫吸附 (ELISA)法 ,在 10 8例原发性肾小球疾病患者 ,测定接受低分子肝素治疗前后 ,纤维蛋白单体聚合功能 (FMPF)及D 二聚体 (D D)的变化 ,并进行对比观察。结果 :治疗前肾小球疾病患者的纤维蛋白单体聚合速率 (FMPV)及纤维蛋白原 (Fbg)有显著或极显著增高 (P <0 .0 5或P <0 .0 1) ;治疗后降低 ,治疗前、后比较差异有显著性 (P<0 .0 5 )。患者在接受抗凝治疗后 ,FMPF较治疗前显著降低 (P <0 .0 5 ) ,抗凝治疗前患者血中的D D明显高于正常人 (P <0 .0 5 ) ,治疗后较治疗前又显著升高 (P <0 .0 5 ) ,与正常对照组比较 ,增高极显著 (P <0 .0 1)。结论 :原发性肾小球疾病患者 ,其高凝状态或血栓形成存在不同程度的差异。但凡有高凝状态或血栓形成之患者 ,经抗凝治疗后 ,FMPF呈显著降低 ,而D D显著升高 ,表明抗凝治疗可获得较好的疗效。OBJECTIVE To investigate the significance of the FMPF and D-D in the therapeutic observation of the anti-coagulation. METHODS Omer polymerization velocity (FMPV) was measured patients with nephritis and healthy individuals.D-D was measured by ELISA. RESULTS The plasma or for levels of FMPV、Fbg、D-D were elevated significancty in all patients tested. After the antithrombosis therapy FMPV in patient with nephritis was found to be reduced significantly than before therapy and D-D raised signifycantly.CONCLUSION This study showed that fibrinogen concentration in these patients raised significantly than the control. FMPV in patients with chronic renal failure raised significantly than the con-trol.After the anticoagulative therapy FMPV in patient with nephritis were found to be reduced significantly than before therapy and D-D raised. FMPV、D-D、may be the risk factor of hypercogulability and thrombosis.

关 键 词：纤维蛋白单体 D-二聚体 低分子肝素 

分 类 号：R973.2[医药卫生—药品]