糖尿病并发心血管疾病的机理研究进展  

Advances of Research on Pathogenesis of Diabetic Cardiovascular Complications

作　　者：孙纪新[1] 翟新灵[1] 符云峰[2] 

机构地区：[1]河北省疾病预防控制中心慢性病防治部,河北石家庄050021 [2]河北省疾病预防控制中心生化研究室,河北石家庄050021

出　　处：《心血管病学进展》2004年第4期299-302,共4页Advances in Cardiovascular Diseases

摘　　要：心血管疾病 (CVDs)是糖尿病常见的并发症和主要死因。糖尿病并发CVDs的主要危险因素包括 :高血压、肥胖、动脉粥样硬化、脂质代谢失常、微蛋白尿、内皮功能失常、血小板高凝聚性、凝血 血纤溶系统活性失常以及糖尿病心肌病等。本文简要综述了糖尿病患者脂质代谢异常、内皮功能失常、蛋白质非酶糖化、氧化应激等病理生理生化变化促使动脉粥样硬化形成和CVDs发生的分子机理。Cardiovascular diseases (CVDs) are the major complications and causes of mortality in persons with diabetes,and many factors including hypertension,obesity,atherosclerosis,dyslipidemia,microalbuminuria,endothelial dysfunction,platelet hyperaggregability,coagulation abnormalities,and diabetic cardiomyopathy,contribute to this high prevalence of CVDs.The molecular mechanisms of atherosclerosis,dyslipidemia,and especially endothelial dysfunction,leading to cardiovascular diseases in diabetes are reviewed briefly.

关 键 词：糖尿病 心血管疾病 研究进展 并发症 

分 类 号：R587.1[医药卫生—内分泌]